Phylogeny and Origins of Hantaviruses Harbored by Bats, Insectivores, and Rodents

PLoS Pathogens

Yong-Zhen Zhang¹  Miao-Ruo Wang²  Run-Hong Zhou³  Wen-Ping Guo³  Ming-Hui Li³  Jianguo Xu³  Jian-Bo Wang³  Wen Wang³  Mei-Li Cong³  Edward C. Holmes⁴  Xian-Dan Lin⁵  Jun-Hua Tian⁶  Hai-Lin Zhang⁷ 

[1] Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America;Longquan Center for Disease Control and Prevention, Longquan, Zhejiang Province, China;State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China;Sydney Emerging Infections and Biosecurity Institute, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia;Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China;Wuhan Center for Disease Control and Prevention, Wuhan, Hubei Province, China;Yunnan Institute of Endemic Diseases Control and Prevention, Dali, China

关键词: Phylogenetic analysis;    Bats;    Hantavirus;    Animal phylogenetics;    Shrews;    Rodents;    Viral evolution;    Phylogeography;   

DOI  :  10.1371/journal.ppat.1003159

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Hantaviruses are among the most important zoonotic pathogens of humans and the subject of heightened global attention. Despite the importance of hantaviruses for public health, there is no consensus on their evolutionary history and especially the frequency of virus-host co-divergence versus cross-species virus transmission. Documenting the extent of hantavirus biodiversity, and particularly their range of mammalian hosts, is critical to resolving this issue. Here, we describe four novel hantaviruses (Huangpi virus, Lianghe virus, Longquan virus, and Yakeshi virus) sampled from bats and shrews in China, and which are distinct from other known hantaviruses. Huangpi virus was found in Pipistrellus abramus, Lianghe virus in Anourosorex squamipes, Longquan virus in Rhinolophus affinis, Rhinolophus sinicus, and Rhinolophus monoceros, and Yakeshi virus in Sorex isodon, respectively. A phylogenetic analysis of the available diversity of hantaviruses reveals the existence of four phylogroups that infect a range of mammalian hosts, as well as the occurrence of ancient reassortment events between the phylogroups. Notably, the phylogenetic histories of the viruses are not always congruent with those of their hosts, suggesting that cross-species transmission has played a major role during hantavirus evolution and at all taxonomic levels, although we also noted some evidence for virus-host co-divergence. Our phylogenetic analysis also suggests that hantaviruses might have first appeared in Chiroptera (bats) or Soricomorpha (moles and shrews), before emerging in rodent species. Overall, these data indicate that bats are likely to be important natural reservoir hosts of hantaviruses.

【 授权许可】

CC BY