Correlation between HIV-1 genotype and clinical progression in HIV/AIDS patients in Surabaya, Indonesia

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Rachman, B.E.^1,2 ; Khairunisa, S.Q.^3 ; Witaningrum, A.M.^3 ; Yunifiar, M.Q.^3 ; Nasronudin^1,2

Airlangga University Hospital, Surabaya, Indonesia^1

Faculty of Medicine, Airlangga University, Surabaya, Indonesia^2

Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia^3

关键词: Beta coefficients;    Blood samples;    Body mass index;    Cell count;    Historical data;    Medical record;    Multi variate analysis;    Phylogenetic analysis;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012002/pdf
DOI  :  10.1088/1755-1315/125/1/012002

来源: IOP

【 摘 要 】

Several factors such as host and viral factors can affect the progression of HIV/AIDS. This study aims to identify the correlation viral factors, especially the HIV-1 subtype with HIV/AIDS progression. Inpatient HIV/AIDS during the period March to September 2017 and willing to participate are included in the study. Historical data of disease and treatment was taken by medical record. Blood samples were amplified, sequenced and undergone phylogenetic analysis. Linear regression analysis was used to estimate beta coefficient (β) and 95%CI of HIV/AIDS progression (measured by the CD4 change rate, ΔCD4 cell count/time span in months).This study has 17 samples. The HIV-1 subtype was dominated by CRF01-AE (81.8%) followed by subtype B (18.2%). There was significant correlation between subtype HIV-1 (p = 0.04) and body mass index (p = 0.038) with HIV/AIDS clinical stage. Many factors were assumed to be correlated with increased rate of CD4, but we only subtype HIV-1 had a significant correlation (p = 0.024) with it. From multivariate analysis, we also found that subtype HIV-1 had a significant correlation (β = 0.788, 95%CI: 17.5-38.6, p = 0.004).