Vinpocetine Inhibits Oligodendroglial Precursor Cell Differentiation

Cellular Physiology and Biochemistry

关键词: Vinpocetine;    IĸB kinase;    Nutritional supplement;    Multiple sclerosis;    Myelin repair;    Oligodendrocyte;   

DOI  :  10.1159/000341451

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Background In multiple sclerosis during periods of remission a limited degree of myelin repair can be observed mediated by oligodendroglial precursor cells. Phosphodiesterase inhibitors act as anti-inflammatory agents and might hold promise for future multiple sclerosis treatment. Aims To investigate whether phosphodiesterase inhibitors could also influence myelin repair. Methods We stimulated primary oligodendroglial precursor cells with cilostazol, rolipram and vinpocetine and assessed their effects on repair related cellular processes. Results We found that vinpocetine exerted a strong negative effect on myelin expression while cilostazol and rolipram did not show such effects. In addition, vinpocetine decreased morphological complexities suggesting an overall negative impact on oligodendroglial cell maturation. We provide evidence that this is not mediated via a blockade of phosphodiesterase-1 but rather by inhibition of IĸB kinase. Conclusion These findings suggest that vinpocetine via IĸB inhibition exerts a strong negative impact on oligodendroglial cell maturation and may therefore provide the rationale to restrict its application during periods of remission in multiple sclerosis patients. This is of particular interest since vinpocetine is widely used as a health supplement thought to act as a cognitive and memory enhancer for healthy people and patients with neurological or muscle diseases.

【 授权许可】

CC BY-NC-ND