Involvement of Immune Regulation in Multiple Sclerosis:

Immunology and Immunogenetics Insights

GabrielleSpagnuolo¹ 

关键词: Multiple sclerosis;    dendritic cells;    T cells;    interleukins;    cytokines;   

DOI  :  10.1177/1178634517734175

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuroinflammation and demyelination that results in axon loss. Multiple sclerosis has been shown to be the result of an autoimmune response caused by a mixture of genetic and environmental factors. Dendritic cells are prominent antigen-presenting cells that interact with various molecules to regulate the immune system. The dysfunction of various features of immune regulation, including interleukins (ILs), CD4+ T cells, and suppressor of cytokine signaling (SOCS1), has been implicated in the pathogenesis of MS. T cells, particularly through the malfunction of B7-costimulatory pathways, have been shown to affect the progression of the disease. SOCS1 is important in regulating the function of T cells through its interactions with other nearby genes, especially CLEC16A, with abnormal decreases in SOCS1 expression leading to the exhibition of MS symptoms. The activation of IL-23 receptors on CD4+ T cells is pivotal to their differentiation into pathogenic TH17 cells. Several promising compounds that downregulate gene expression of IL-23 and IL-23R have been discovered but require further investigation for efficacy and safety. Given their role in the severity and progression of MS, therapies that decrease these dysregulations may ultimately decrease symptoms and in turn improve patients’ quality of life.

【 授权许可】

CC BY