Transport processes of radiopharmaceuticals and -modulators

Radiation Oncology

Peter Langguth¹  Thomas Efferth² 

[1] Department of Pharmaceutical Technology and Biopharmacy, Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Mainz, Germany;Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Mainz, Germany

关键词: Radiochemotherapy;    Radioprotection;    Radioresistance;    Multidrug resistance;    ABC transporter;   

Others  :  1224369
DOI  :  10.1186/1748-717X-6-59

 received in 2011-02-18, accepted in 2011-06-06,  发布年份 2011

【 摘 要 】

Radiotherapy and radiology have been indispensable components in cancer care for many years. The detection limit of small tumor foci as well as the development of radio-resistance and severe side effects towards normal tissues led to the development of strategies to improve radio-diagnostic and -therapeutic approaches by pharmaceuticals. The term "radiopharmaceutical" has been used for drugs labeled with radioactive tracers for therapy or diagnosis. In addition, drugs have been described to sensitize tumor cells to radiotherapy (radiosensitizers) or to protect normal tissues from detrimental effects of radiation (radioprotectors). The present review summarizes recent concepts on the transport of radiopharmaceuticals, radiosensitizers, and radioprotectors in cells and tissues, e.g. by ATP-binding cassette transporters such as P-glycoprotein. Strengths and weaknesses of current strategies to improve transport-based processes are discussed.

【 授权许可】

   
2011 Efferth and Langguth; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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