Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

Molecular Cancer

Xianwei Wang¹  Chaochu Cui²  Xiao Li²  Dongling Liu²  Jianbo Yang³  Liwu Fu⁴ 

[1] Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center;Henan Key Laboratory of Medical Tissue Regeneration, College of Basic Medical Sciences, Xinxiang Medical University;School of Laboratory Medicine, Xinxiang Medical University;State Key Laboratory of Oncology in South China;

关键词: circRNAs;    Cancer therapy;    Sensitivity;    Radioresistance;    Chemoresistance;    Multidrug resistance;   

DOI  :  10.1186/s12943-020-01180-y

来源: DOAJ

【 摘 要 】

Abstract Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to manipulate the functions of diverse molecules, including non-coding RNAs, mRNAs, DNAs and proteins, to regulate cell activities in physiology and pathology. Accumulating evidence indicates that circRNAs play critical roles in tumor genesis, development, and sensitivity to radiation and chemotherapy. Radiotherapy and chemotherapy are two primary types of intervention for most cancers, but their therapeutic efficacies are usually retarded by intrinsic and acquired resistance. Thus, it is urgent to develop new strategies to improve therapeutic responses. To achieve this, clarification of the underlying mechanisms affecting therapeutic responses in cancer is needed. This review summarizes recent progress and mechanisms of circRNAs in cancer resistance to radiation and chemotherapy, and it discusses the limitations of available knowledge and potential future directions.

【 授权许可】

Unknown