Zingiberaceae extracts for pain: a systematic review and meta-analysis

Nutrition Journal

Deborah Tepper³  Christopher T. Ford¹  Shaheen E. Lakhan² 

[1] Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, The University of Liverpool, Liverpool, UK;Global Neuroscience Initiative Foundation, Los Angeles, California, USA;Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA

关键词: Curcuma;    Curcumin;    Galangal;    Turmeric;    Ginger;    VAS;   

Others  :  1222663
DOI  :  10.1186/s12937-015-0038-8

 received in 2015-03-21, accepted in 2015-05-06,  发布年份 2015

【 摘 要 】

Background

Members of the family Zingiberaceae including turmeric, ginger, Javanese ginger, and galangal have been used for centuries in traditional medicine. Preclinical studies of Zingiberaceae extracts have shown analgesic properties. This study aims to systematically review and meta-analyze whether extracts from Zingiberaceae are clinically effective hypoalgesic agents.

Methods

Literature was screened from electronic databases using the key words Zingiberaceae AND pain OR visual analogue score (VAS) to identify randomized trials. From this search, 18 studies were identified, and of these, 8 randomized, double-blinded, placebo-controlled trials were found that measured pain by VAS for inclusion in the meta-analysis.

Results

Findings indicated significant efficacy of Zingiberaceae extracts in reducing subjective chronic pain (SMD − 0.67; 95 % CI − 1.13 to − 0.21; P = 0.004). A linear dose-effect relationship was apparent between studies (R² = 0.71). All studies included in the systematic review reported a good safety profile for extracts, without the renal risks associated with non-steroidal anti-inflammatory drugs, and with similar effectiveness.

Conclusion

Our findings indicated that Zingiberaceae extracts are clinically effective hypoalgesic agents and the available data show a better safety profile than non-steroidal anti-inflammatory drugs. However, both non-steroidal anti-inflammatory drugs and Zingiberaceae have been associated with a heightened bleeding risk, and there have been no comparator trials of this risk. Further clinical studies are recommended to identify the most effective type of Zingiberaceae extract and rigorously compare safety, including bleeding risk.

【 授权许可】

   
2015 Lakhan et al.; licensee BioMed Central.

【 图 表 】

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