Efficacy of oral consumption of curcumin/ for symptom improvement in inflammatory bowel disease: A systematic review of animal models and a meta-analysis of randomized clinical trials

Biocell

article

MARLA DE CERQUEIRA ALVES¹  MONISE OLIVEIRA SANTOS¹  NASSIB BEZERRA BUENO¹  ORLANDO ROBERTO PIMENTEL DE ARAÚJO²  MARÍLIA OLIVEIRA FONSECA GOULART²  FABIANA ANDRÉA MOURA¹ 

[1] Programa de Pós-Graduação em Nutrição ,(PPGNUT), Universidade Federal de Alagoas;Instituto de Química e Biotecnologia ,(IQB), Universidade Federal de Alagoas;Programa de Pós-Graduação em Ciências da Saúde ,(PPGCS), Universidade Federal de Alagoas;Programa de Pós-Graduação da Rede Nordeste de Biotecnologia ,(RENORBIO), Universidade Federal de Alagoas;Programa de Pós-Graduação em Ciências Médicas ,(PPGCM), Universidade Federal de Alagoas

关键词: Ulcerative colitis;    Crohn’s disease;    Oxidative stress;    Curcuma;    Turmeric;   

DOI  :  10.32604/biocell.2022.020407

学科分类：仪器

来源: Biocell

【 摘 要 】

The roots of the vegetal Curcuma due to its high content of polyphenols, has been used successfully in several clinical situations. This review assessed the effect of curcumin/Curcuma longa on symptoms and metabolic changes in inflammatory bowel disease (IBD). A systematic review of animal models and randomized clinical trials (RCTs) was conducted by searching the following electronic databases: PubMed, CENTRAL, LILACS, Science Direct, and ClinicalTrials.gov. From 997 found records, 62 were included. More than 90% of the animal studies reported an improvement in macroscopic, histologic and/or functional activity; 80% identified decreased oxidative and/or inflammatory biomarkers in animals treated with curcumin. Among the RCTs, intention-to-treat analysis showed that oral curcumin was effective in inducing clinical remission (n = 281, RR: 3.15 CI 95% [1.22–8.10] p = 0.0017; i² = 72.2%, p = 0.006) and clinical response (n = 259, RR: 1.60 CI 95% [1.09–2.35] p = 0.0017; i² = 59.7%, p = 0.042) but not endoscopic remission (n = 161, RR: 2.91 CI 95% [0.58–14.58] p = 0.195; i² = 72.7%, p = 0.026). These results confirm that oral supplementation with curcumin/Curcuma longa has beneficial actions in animal colitis and, when associated with drug therapy, is effective in the treatment of patients with IBD.

【 授权许可】

CC BY