Colorectal Cancer associated with pediatric inflammatory bowel disease: a case series

BMC Pediatrics

Hyun Young Kim¹  Min Jee Kim²  Jae Sung Ko²  Soo Young Moon²  Jong Woo Hahn²  Minsoo Shin²  Jin Soo Moon² 

[1] Department of Pediatric Surgery, Seoul National University College of Medicine, Seoul National University Children’s Hospital, Seoul, Republic of Korea;Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children’s Hospital, 101 Daehak-ro, Jongno-Gu, 03080, Seoul, Republic of Korea;

关键词: Pediatric-onset inflammatory bowel disease;    Colorectal cancer;    Crohn’s disease;    Ulcerative colitis;    Surveillance endoscopy;   

DOI  :  10.1186/s12887-021-02966-9

来源: Springer

【 摘 要 】

BackgroundInflammatory bowel disease (IBD) is associated with an increased risk of Colorectal cancer (CRC), and its most important risk factors are the duration and extent of the disease. Pediatric-onset inflammatory bowel disease has a tendency for a more extensive, more severe, and longer predicted disease duration than adult-onset inflammatory bowel disease. This study aimed to identify the clinical characteristics of patients with CRC related to pediatric-onset IBD and consider the appropriateness of current surveillance endoscopy recommendations for the detection of premalignant lesions and early-stage CRC.MethodsWe searched a research platform based on the SUPREME electronic medical record data-mining system to identify cases of colorectal malignancy in patients with pediatric IBD that presented between 2000 and 2020.ResultsDuring the follow-up, 4 (1.29 per 1000 person years) out of 443 patients with PIBD was diagnosed with CRC. The median age at diagnosis of CRC was 18.5 (range: 15–24) years, and the median period from diagnosis of IBD to CRC was 9.42 (range: 0.44–11.96) years. The sigmoid colon was the most frequent location of CRC (in 3 of the 4 cases). Adenocarcinoma was the most common histological type (in 2 of the 4 cases).ConclusionsPatients with pediatric-onset IBD exhibited a much shorter disease duration than that of adult-onset IBD at the time of diagnosis of CRC, suggesting that surveillance endoscopy for the detection of precancerous lesions and early-stage cancer should be initiated earlier in pediatric patients than in adult patients.

【 授权许可】

CC BY