Racial differences between African-American and white women in insulin resistance and visceral adiposity are associated with differences in apoCIII containing apoAI and apoB lipoproteins

Nutrition & Metabolism

Anne E Sumner²  Amber B Courville⁴  Madia Ricks²  Jeremy D Furtado³  Frank M Sacks¹  Liyun Wang³ 

[1]Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

[2]Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

[3]Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 1, Room 201, Boston, MA 02115, USA

[4]Nutrition Department, Clinical Center, National Institutes of Health, Bethesda, Maryland

关键词: Coronary heart disease;    African-Americans;    Insulin resistance;    Visceral adipose tissue;    ApoB lipoproteins;    HDL;    ApoCIII;    ApoAI;   

Others  :  1130854
DOI  :  10.1186/1743-7075-11-56

 received in 2014-10-21, accepted in 2014-12-05,  发布年份 2014

【 摘 要 】

Background

African-Americans have higher HDL, less visceral adipose tissue (VAT) and lower triglyceride (TG) and apoCIII concentrations than whites, despite being more insulin-resistant. We studied in African-American and white women the influences of insulin resistance and VAT on the apoAI concentrations of two HDL subspecies, one that contains apoCIII that is associated with increased risk of coronary heart disease (CHD) and one that does not have apoCIII that is associated with decreased CHD; and on the apoCIII concentrations of HDL and of the apoB lipoproteins.

Methods

The participants were 32 women (14 African-Americans, 18 white) of similar age (39 ± 12 vs. 42 ± 11y). Mean BMI was 34 kg/m² in the African-Americans compared to 30 in the whites. A standard diet (33% fat, 52% carbohydrate, 15% protein) was provided for 7 days followed by a test meal (40% fat, 40% carbohydrate, 20% protein) on Day 8. Insulin sensitivity index (S_I) was calculated from the minimal model.

Results

After controlling for S_I, African-Americans have a higher mean apoAI level in HDL with apoCIII compared with whites (12.9 ± 2.8 and 10.9 ± 2.9 mg/dL, respectively, P = 0.05). S_I was associated with higher apoAI in HDL with apoCIII, whereas VAT was not associated with this HDL subspecies. This pattern of results was reversed for apoCIII concentrations in apoB lipoproteins. After adjusting for S_I, African-Americans had lower apoCIII in apoB lipoproteins. S_I was associated with lower apoCIII in total apoB lipoproteins, whereas VAT was associated with higher apoCIII in all the apoB lipoproteins. Additional adjustment for VAT tended to reduce the difference in apoCIII between the groups.

Conclusions

African-American women have a higher HDL with apoCIII level than whites when controlled for insulin sensitivity. African-Americans have lower insulin sensitivity. Insulin sensitivity is associated with higher levels of HDL with apoCIII. ApoCIII levels in VLDL are lower in African-American women than whites, also affected by insulin sensitivity which is associated with low apoCIII in VLDL. VAT has a strong association with apoCIII in apoB lipoproteins but not with apoAI in HDL with apoCIII.

Trial registration

ClinicalTrials.gov Identifier: NCT00484861

【 授权许可】

   
2014 Wang et al.; licensee BioMed Central.

【 图 表 】

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