Expression of bcl-2 and p53 in bovine cutaneous fibropapillomas

Infectious Agents and Cancer

Giuseppe Borzacchiello²  Elena Velescu¹  Annunziata Corteggio²  Gennaro Altamura²  Florentina Bocaneti¹ 

[1]Department of Public Health, Faculty of Veterinary Medicine, University of Agriculture Sciences and Veterinary Medicine, Ion Ionescu de la, Brad, Iasi, Romania

[2]Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino, 1 80137 Napoli, Italy

关键词: Fibropapilloma;    Cattle;    Bovine papillomavirus;   

Others  :  1133742
DOI  :  10.1186/1750-9378-10-2

 received in 2014-09-25, accepted in 2014-12-15,  发布年份 2015

【 摘 要 】

Background

Bovine cutaneous fibropapillomas are benign hyperproliferative lesions induced by Bovine Papillomaviruses (BPVs). Bcl-2 is an important anti-apoptotic protein which is expressed in several cancer types. In contrary, p53 is a tumour suppressor protein that mediates cell cycle arrest, apoptosis and senescence in response to cellular stresses.

Findings

Here, we investigated immunohistochemically and biochemically, the expression of bcl-2 and p53 in a subset of BPV positive fibropapillomas and bovine normal skin. Normal skin samples showed a weak signal for both proteins in the cytoplasm of the basal cells. Nine out of twelve (75%) tumour samples stained positive for bcl-2 throughout basal and parabasal layers, with most of cells showing strong cytoplasmic immunoreactivity. Nine out of twelve (75%) fibropapillomas were found to be positive for p53 expression, showing a strong cytoplasmic and perinuclear staining of p53 protein mainly in the basal and parabasal layers.

Conclusions

Our data reveal an altered bcl-2 and p53 immunoreactivity in bovine cutaneous fibropapillomas, suggesting involvement of these two proteins in the cutaneous neoplastic transformation through an impaired apoptotic process.

【 授权许可】

   
2015 Bocaneti et al.; licensee BioMed Central.

【 图 表 】

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