Complex roles of filamin-A mediated cytoskeleton network in cancer progression

Cell & Bioscience

Zhiyuan Shen²  Steven Huhn²  Jingyin Yue¹ 

[1] Current address: Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA;Department of Radiation Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA

关键词: Metastasis;    DNA repair;    Cytoskeleton;    Actin filament;    ABP-280;    Filamin-A;   

Others  :  792983
DOI  :  10.1186/2045-3701-3-7

 received in 2012-12-27, accepted in 2013-01-10,  发布年份 2013

【 摘 要 】

Filamin-A (FLNA), also called actin-binding protein 280 (ABP-280), was originally identified as a non-muscle actin binding protein, which organizes filamentous actin into orthogonal networks and stress fibers. Filamin-A also anchors various transmembrane proteins to the actin cytoskeleton and provides a scaffold for a wide range of cytoplasmic and nuclear signaling proteins. Intriguingly, several studies have revealed that filamin-A associates with multiple non-cytoskeletal proteins of diverse function and is involved in several unrelated pathways. Mutations and aberrant expression of filamin-A have been reported in human genetic diseases and several types of cancer. In this review, we discuss the implications of filamin-A in cancer progression, including metastasis and DNA damage response.

【 授权许可】

   
2013 Yue et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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