Association of cardiac autonomic neuropathy with arterial stiffness in type 2 diabetes mellitus patients

Journal of Diabetes & Metabolic Disorders

Hossein Fakhrzadeh⁶  Sudabeh Alatab⁵  Zohre Badamchizade⁵  Morteza Abdar Esfahani¹  Farshad Sharifi⁵  Akbar Shafiee³  Yaser Tajallizade-Khoob⁵  Afshin Nejati-Afkham⁴  Ataollah Bagherzadeh² 

[1] Cardiology Department, St alzahr hospital, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Internal Medicine, Cardiology & Cardiac Electrophysiology, Dr Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran;Department of Cardiovascular Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran;Department of Cardiology, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;Elderly Health Research Center, Endocrinology and Metabolism population Sciences Institute, Tehran University of Medical Sciences, North Karegar Avenue, Dr Shariati Hospital, 5th floor, Tehran 1411413137, Iran;Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

关键词: Cardiac autonomic neuropathy;    Diabetes mellitus type 2;    Pulse wave velocity;    Arterial stiffness;    Heart rate variability;   

Others  :  806709
DOI  :  10.1186/2251-6581-12-55

 received in 2013-07-31, accepted in 2013-09-30,  发布年份 2013

【 摘 要 】

Background

Diabetic patients are at the risk of cardiac autonomic neuropathy (CAN) and arterial stiffness. This study aimed to investigate the association of heart rate variability (HRV) as an index for CAN and pulse wave velocity (PWV) as an index for arterial stiffness.

Methods

Uncomplicated diabetes type-2 patients who had no apparent history of cardiovascular condition underwent HRV and PWV measurements and the results were compared with the control group consisting of non-diabetic peers. Also, the findings were adjusted for the cardiovascular risk factors and other confounding factors.

Results

A total of 64 diabetic patients (age= 52.08±8.50 years; males=33 [51.6%]) were compared with 57 controls (age= 48.74±6.18 years; males=25 [43.9%]) in this study. Hypertension, dyslipidemia, and thereby systolic blood pressure and statin use were significantly more frequent in the diabetic group, while the serum levels of cholesterol, HDL-C and LDL-C were significantly higher in the controls. Pulse wave was significantly increased in the diabetic patients (p<0.001). Main HRV parameters were significantly lower in diabetics than in controls. After adjustment for the confounders, PWV and HRV remained significantly different between the groups (p=0.01 and p=0.004, respectively). Multiple logistic regression of the association between pulse wave velocity and HRV index was independently significant both in diabetics and controls.

Conclusions

There exists a significant relationship between heart rate variability and arterial stiffness as a measure for atherosclerosis in diabetic patients, although the role of the confounding factors is noteworthy.

【 授权许可】

   
2013 Bagherzadeh et al.; licensee BioMed Central Ltd.

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