Positive correlation of serum adipocyte fatty acid binding protein levels with carotid–femoral pulse wave velocity in geriatric population

BMC Geriatrics

Bang-Gee Hsu³  Yu-Chih Chen²  Chung-Jen Lee¹  Ji-Hung Wang²  Jen-Pi Tsai⁴ 

[1] Department of Nursing, Tzu Chi College of Technology, Hualien, Taiwan;Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;Division of Nephrology, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Chung-Yang Road, Hualien 97002, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan

关键词: Pulse wave velocity;    Geriatric adults;    Arterial stiffness;    Adipocyte fatty acid binding protein;   

Others  :  1220847
DOI  :  10.1186/s12877-015-0089-x

 received in 2015-04-07, accepted in 2015-07-16,  发布年份 2015

【 摘 要 】

Background

Adipocyte fatty acid binding protein (A-FABP) is a novel fat-derived circulating protein, which is independently and positively associated with atherosclerosis. The present study evaluated the relationship between fasting serum A-FABP and central arterial stiffness in geriatric adults.

Methods

Fasting blood samples were obtained from 87 geriatric patients and the serum A-FABP levels were measured using an enzyme immunoassay. Carotid-femoral pulse wave velocity (cfPWV) was determined using the SphygmoCor system. cfPWV values of >10 m/s represented the high arterial stiffness group, while values ≤10 m/s defined the low arterial stiffness group.

Results

High arterial stiffness group comprised of 42 geriatric adults (48.3 %). When compared to those in the low arterial stiffness group, the high arterial stiffness group had a higher rate of diabetes mellitus (P = 0.044) and hypertension (P = 0.043). Body weight (P = 0.027), waist circumference (P = 0.035), body mass index (P = 0.001), systolic blood pressure (P = 0.005), diastolic blood pressure (P = 0.045), pulse pressure (P = 0.038), and serum A-FABP level (P < 0.001) were also higher in the high arterial stiffness group than in the low arterial stiffness group. Multivariate logistic regression analysis of the factors significantly associated with arterial stiffness revealed that A-FABP (odds ratio: 1.833, 95 % confidence interval 1.123–2.993, P = 0.015) was an independent predictor of arterial stiffness in geriatric adults.

Conclusions

Serum A-FABP levels constitute a major risk factor in the development of central arterial stiffness in the geriatric population.

【 授权许可】

   
2015 Tsai et al.

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