Positive correlation of serum adipocyte fatty acid binding protein levels with carotid–femoral pulse wave velocity in geriatric population

BMC Geriatrics

Research Article

Chung-Jen Lee¹  Yu-Chih Chen²  Jen-Pi Tsai³  Ji-Hung Wang⁴  Bang-Gee Hsu⁵ 

[1] Department of Nursing, Tzu Chi College of Technology, Hualien, Taiwan;Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;Division of Nephrology, Buddhist Tzu Chi General Hospital, Dalin Branch, Chia-Yi, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan;Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan;Division of Nephrology, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Chung-Yang Road, 97002, Hualien, Taiwan;

关键词: Adipocyte fatty acid binding protein;    Arterial stiffness;    Geriatric adults;    Pulse wave velocity;   

DOI  :  10.1186/s12877-015-0089-x

 received in 2015-04-07, accepted in 2015-07-16,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAdipocyte fatty acid binding protein (A-FABP) is a novel fat-derived circulating protein, which is independently and positively associated with atherosclerosis. The present study evaluated the relationship between fasting serum A-FABP and central arterial stiffness in geriatric adults.MethodsFasting blood samples were obtained from 87 geriatric patients and the serum A-FABP levels were measured using an enzyme immunoassay. Carotid-femoral pulse wave velocity (cfPWV) was determined using the SphygmoCor system. cfPWV values of >10 m/s represented the high arterial stiffness group, while values ≤10 m/s defined the low arterial stiffness group.ResultsHigh arterial stiffness group comprised of 42 geriatric adults (48.3 %). When compared to those in the low arterial stiffness group, the high arterial stiffness group had a higher rate of diabetes mellitus (P = 0.044) and hypertension (P = 0.043). Body weight (P = 0.027), waist circumference (P = 0.035), body mass index (P = 0.001), systolic blood pressure (P = 0.005), diastolic blood pressure (P = 0.045), pulse pressure (P = 0.038), and serum A-FABP level (P < 0.001) were also higher in the high arterial stiffness group than in the low arterial stiffness group. Multivariate logistic regression analysis of the factors significantly associated with arterial stiffness revealed that A-FABP (odds ratio: 1.833, 95 % confidence interval 1.123–2.993, P = 0.015) was an independent predictor of arterial stiffness in geriatric adults.ConclusionsSerum A-FABP levels constitute a major risk factor in the development of central arterial stiffness in the geriatric population.

【 授权许可】

Unknown   
© Tsai et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.