Association of Genetic polymorphism of PPARγ-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus

Journal of Biomedical Science

Farzana Mahdi¹  Saliha Rizvi¹  Absar Ahmad¹  Faisal Ahmed¹  Syed Tasleem Raza¹  Shania Abbas¹ 

[1] Molecular Biology Lab, Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow 226003, India

关键词: Type 2 diabetes mellitus;    Fat mass and obesity associated gene;    Fatty acid binding protein-2;    Methylene tetrahydrofolate reductase;    Angiotensin converting enzyme;    Peroxisome proliferator-activated receptor gamma;    Genetic polymorphism;    Single nucleotide polymorphism;    Genome sequencing;   

Others  :  821935
DOI  :  10.1186/1423-0127-20-80

 received in 2013-07-06, accepted in 2013-10-01,  发布年份 2013

【 摘 要 】

Type 2 diabetes mellitus (T2DM) is a non-autoimmune, complex, heterogeneous and polygenic metabolic disease condition characterized by persistent elevated blood glucose levels (hyperglycemia). India as said to be the diabetic capital of the world is likely to experience the largest increase in T2DM and a greater number of diabetic individuals in the world by the year 2030. Identification of specific genetic variations in a particular ethnic group has a critical role in understanding the risk of developing T2DM in a much efficient way in future. These genetic variations include numerous types of polymorphisms among which single nucleotide polymorphisms (SNPs) is the most frequent. SNPs are basically located within the regulatory elements of several gene sequences. There are scores of genes interacting with various environmental factors affecting various pathways and sometimes even the whole signalling network that cause diseases like T2DM. This review discusses the biomarkers for early risk prediction of T2DM. Such predictions could be used in order to understand the pathogenesis of T2DM and to better diagnostics, treatment, and eventually prevention.

【 授权许可】

   
2013 Abbas et al.; licensee BioMed Central Ltd.

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