The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus

BMC Endocrine Disorders

Bekir Cakir¹  Reyhan Ersoy¹  Cafer Kaya¹  Rifki Ucler¹  Sedat Caner¹  Fevzi Balkan¹  Celil Alper Usluogullari¹ 

[1] Clinic of Endocrinology and Metabolism, Atatürk Training and Research Hospital, Ankara, Turkey

关键词: Microvascular complications;    25-hydroxyvitamin D;    Type 2 diabetes mellitus;   

Others  :  1215933
DOI  :  10.1186/s12902-015-0029-y

 received in 2014-08-15, accepted in 2015-06-10,  发布年份 2015

【 摘 要 】

Background

Vitamin D deficiency is reported as a possible risk factor for the development of diabetes in several epidemiologic studies. In this study, we investigated the frequency of 25-OH vitamin D deficiency in type 2 diabetes mellitus and the relationship between 25-OH vitamin D deficiency and the prevalence of microvascular complications.

Methods

In this retrospective study, we evaluated the medical records of 557 patients with type 2 diabetes admitted to the Endocrinology Outpatient Clinic from January to March 2010 and 112 healthy controls randomly selected from individuals admitted to the hospital for a check-up and who had a laboratory result for serum 25-OH vitamin D concentrations at screening. The levels of 25-OH vitamin D in patients with type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications were investigated.

Results

No significant difference in serum 25-OH vitamin D concentrations was observed between the diabetic and control groups. No correlation was observed between HbA _1Cand serum 25-OH vitamin D levels. Serum 25-OH vitamin D levels were lower in diabetic patients with nephropathy, and patients not using any medication, i.e., those treated with dietary changes alone, had a higher prevalence of nephropathy.

Conclusion

Vitamin D deficiency is more common in diabetic patients with nephropathy. When microvascular complications were evaluated, vitamin D levels were found to be lower in patients in whom these complications were more severe. Vitamin D deficiency is therefore associated with microvascular complications in diabetic patients.

【 授权许可】

   
2015 Usluogullari et al.

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