BMC Endocrine Disorders | |
The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus | |
Bekir Cakir1  Reyhan Ersoy1  Cafer Kaya1  Rifki Ucler1  Sedat Caner1  Fevzi Balkan1  Celil Alper Usluogullari1  | |
[1] Clinic of Endocrinology and Metabolism, Atatürk Training and Research Hospital, Ankara, Turkey | |
关键词: Microvascular complications; 25-hydroxyvitamin D; Type 2 diabetes mellitus; | |
Others : 1215933 DOI : 10.1186/s12902-015-0029-y |
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received in 2014-08-15, accepted in 2015-06-10, 发布年份 2015 | |
【 摘 要 】
Background
Vitamin D deficiency is reported as a possible risk factor for the development of diabetes in several epidemiologic studies. In this study, we investigated the frequency of 25-OH vitamin D deficiency in type 2 diabetes mellitus and the relationship between 25-OH vitamin D deficiency and the prevalence of microvascular complications.
Methods
In this retrospective study, we evaluated the medical records of 557 patients with type 2 diabetes admitted to the Endocrinology Outpatient Clinic from January to March 2010 and 112 healthy controls randomly selected from individuals admitted to the hospital for a check-up and who had a laboratory result for serum 25-OH vitamin D concentrations at screening. The levels of 25-OH vitamin D in patients with type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications were investigated.
Results
No significant difference in serum 25-OH vitamin D concentrations was observed between the diabetic and control groups. No correlation was observed between HbA 1Cand serum 25-OH vitamin D levels. Serum 25-OH vitamin D levels were lower in diabetic patients with nephropathy, and patients not using any medication, i.e., those treated with dietary changes alone, had a higher prevalence of nephropathy.
Conclusion
Vitamin D deficiency is more common in diabetic patients with nephropathy. When microvascular complications were evaluated, vitamin D levels were found to be lower in patients in whom these complications were more severe. Vitamin D deficiency is therefore associated with microvascular complications in diabetic patients.
【 授权许可】
2015 Usluogullari et al.
【 预 览 】
Files | Size | Format | View |
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20150626010432522.pdf | 399KB | download |
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