Neurovascular pathophysiology in cerebral ischemia, dementia and the ageing brain – current trends in basic, translational and clinical research

Experimental & Translational Stroke Medicine

Dominik Michalski²  Alexander Kranz¹  Daniel-Christoph Wagner¹  Georg Reiser⁴  Klaus G Reymann³  Christoph Kleinschnitz⁵  Johannes Boltze¹ 

[1] Translational Centre for Regenerative Medicine, University of Leipzig, Philipp-Rosenthal-Str. 55, D-04103 Leipzig, Germany;Department of Neurology, University of Leipzig, Liebigstr. 20, D-04103, Leipzig Germany;German Centre for Neurodegenerative Diseases (DZNE), site Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany;Institute of Neurobiochemistry, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany;Department of Neurology, University of Würzburg, Josef-Schneider-Str. 11, D-97080 Würzburg, Germany

关键词: Translational research;    in vivo imaging;    Astrogliosis;    Mitochondria;    Vascular dementia;    Small vessel disease;    Alzheimer’s disease;    Cerebral ischemia;    Neurorepair;    Neuroprotection;   

Others  :  861826
DOI  :  10.1186/2040-7378-4-14

 received in 2012-07-31, accepted in 2012-08-03,  发布年份 2012

【 摘 要 】

The 7^th International Symposium on Neuroprotection and Neurorepair was held from May 2^nd to May 5^th, 2012 in Potsdam, Germany. The symposium, which directly continues the successful Magdeburg meeting series, attracted over 330 colleagues from 29 countries to discuss recent findings and advances in the field. The focus of the 2012 symposium was widened from stroke and traumatic brain injury to neurodegenerative diseases, notably dementia, and more generally the ageing brain. Thereby, emphasis was given on neurovascular aspects of neurodegeneration and stroke including the blood–brain barrier, recent findings regarding the pathomechanism of Alzheimer’s disease, and brain imaging approaches. In addition, neurobiochemical aspects of neuroprotection, the role of astrogliosis, the clinical progress of cell-based approaches as well as translational hurdles and opportunities were discussed in-depth. This review summarizes some of the most stimulating discussions and reports from the meeting.

【 授权许可】

   
2012 Boltze et al.; licensee BioMed Central Ltd.

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