Epigenetic regulation in adult stem cells and cancers

Cell & Bioscience

Xin Chen¹  Lama Tarayrah¹ 

[1] Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA

关键词: Cancer stem cell;    Cancer;    Epigenetics;    Hair follicle stem cell;    Intestinal stem cell;    Germline stem cell;    Adult stem cell;   

Others  :  791479
DOI  :  10.1186/2045-3701-3-41

 received in 2013-07-19, accepted in 2013-09-05,  发布年份 2013

【 摘 要 】

Adult stem cells maintain tissue homeostasis by their ability to both self-renew and differentiate to distinct cell types. Multiple signaling pathways have been shown to play essential roles as extrinsic cues in maintaining adult stem cell identity and activity. Recent studies also show dynamic regulation by epigenetic mechanisms as intrinsic factors in multiple adult stem cell lineages. Emerging evidence demonstrates intimate crosstalk between these two mechanisms. Misregulation of adult stem cell activity could lead to tumorigenesis, and it has been proposed that cancer stem cells may be responsible for tumor growth and metastasis. However, it is unclear whether cancer stem cells share commonalities with normal adult stem cells. In this review, we will focus on recent discoveries of epigenetic regulation in multiple adult stem cell lineages. We will also discuss how epigenetic mechanisms regulate cancer stem cell activity and probe the common and different features between cancer stem cells and normal adult stem cells.

【 授权许可】

   
2013 Tarayrah and Chen; licensee BioMed Central Ltd.

【 图 表 】

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