Clinical impact of circulating miR-133, miR-1291 and miR-663b in plasma of patients with acute myocardial infarction

Diagnostic Pathology

Huang Zhen-wen²  Hu Tian-yong³  Li Wei-guo¹  Liu Yang-gui¹  Dang Yan-ping¹  Li Yun-fu¹  Wang Zi-hao¹  Ding Xue-zhi¹  Li Bei-fang¹  Qiu Chun-guang²  Liu Peng³ 

[1] Department of Cardiology, Hebi City People’s Hospital, Hebi 458000, China;Department of Cardiology, the First affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;Department of Cardiology, Henan Province Chest Hospital, Zhengzhou 450003, China

关键词: Biomarker;    Diagnosis;    Micro RNA;    Acute myocardial infarction;   

Others  :  1228632
DOI  :  10.1186/1746-1596-9-89

 received in 2014-03-15, accepted in 2014-04-02,  发布年份 2014

【 摘 要 】

Background

Acute myocardial infarction (AMI) is one of the leading causes for death in both developed and developing countries and it is the single largest cause of death in the United States, responsible for 1 out of every 6 deaths. The objective of this study was to determine microRNA (miRNA) expression in AMI and determine whether miR-133, miR-1291 and miR-663b could be measured in plasma as a biomarker for recurrence.

Methods

Patients with AMI and those without AMI were retrospectively recruited for a comparison of their plasma miR-133, miR-1291 and miR-663b expression.

Results

miR-133, miR-1291 and miR-663b levels were significantly overexpressed in AMI compared with Non-AMI. MiR-133 showed an AUC of 0.912, with a sensitivity of 81.1% and a specificity of 91.2%. The AUC for miR-1291 was 0.695, with a sensitivity of 78.4% and a specificity of 89.5%. The AUC for miR-663b was 0.611, with a sensitivity of 72.4% and a specificity of 76.5%.

Conclusions

This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with AMI. The potential of these miRNAs as biomarkers to improve patient stratification according to the risk of AMI and as circulating biomarkers for the AMI progonos warrants further study.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8183629061241474 webcite

【 授权许可】

   
2014 Peng et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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