Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans

PSYCHIATRY RESEARCH

卷:251

Article

Martin, Christiana G.¹  Kim, Hyungsuk¹  Yun, Sijung²  Livingston, Whitney¹  Fetta, Joseph¹  Mysliwiec, Vincent³  Baxter, Tristin³  Gill, Jessica M.¹ 

[1] NINR, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA

[2] Yotta Biomed, Potomac, MD 20854 USA

[3] Madigan Army Med Ctr, 9040A Fitzsimmons Ave, Tacoma, WA 98431 USA

关键词: PTSD;    Micro RNA;    Biomarker;   

DOI  :  10.1016/j.psychres.2017.01.081

来源: Elsevier

【 摘 要 】

Posttraumatic stress disorder (PTSD) affects many returning combat veterans, but underlying biological mechanisms remain unclear. In order to compare circulating micro RNA (miRNA) of combat veterans with and without PTSD, peripheral blood from 24 subjects was collected following deployment, and isolated miRNA was sequenced. PTSD was associated with 8 differentially expressed miRNA. Pathway analysis shows that PTSD is related to the axon guidance and Wnt signaling pathways, which work together to support neuronal development through regulation of growth cones. PTSD is associated with miRNAs that regulate biological functions including neuronal activities, suggesting that they play a role in PTSD symptomatology.

【 授权许可】

Free