Immunoglobulin genes and diversity: what we have learned from domestic animals

Journal of Animal Science and Biotechnology

Yaofeng Zhao²  Ning Li²  Ping Wang²  Zhiguo Wei³  Liming Ren²  Zhancai Liu¹  Yi Sun² 

[1] Department of Biochemistry, Jiaozuo Teachers Colleague, Jiaozuo, 454001, Henan, P. R. China;State Key Laboratory of Agrobiotechnology, College of Biological Sciences; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, P. R. China;College of Animal Science and Technology, Henan University of Science and Technology, Henan, 471003, P. R. China

关键词: Immunoglobulin gene;    Domestic animals;    Diversity;   

Others  :  814165
DOI  :  10.1186/2049-1891-3-18

 received in 2012-02-17, accepted in 2012-06-11,  发布年份 2012

【 摘 要 】

This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α. Two poultry species (chickens and ducks) express three IgH isotypes, μ, υ, and α, but not δ. The κ and λ light chains are both utilized in the four livestock species, but only the λ chain is expressed in poultry. V(D)J recombination, somatic hypermutation (SHM), and gene conversion (GC) are three distinct mechanisms by which immunoglobulin variable region diversity is generated. Different domestic animals may use distinct means to diversify rearranged variable regions of Ig genes.

【 授权许可】

   
2012 Sun et al.; licensee BioMed Ltd.

【 图 表 】

Figure 1.

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