Chromosomal loop anchorage sites appear to be evolutionarily conserved

FEBS Letters

Garrard, William T.¹  Cockerill, Peter N.¹ 

[1] Department of Biochemistry, The University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA

关键词: Nuclear matrix;    Nuclear scaffold;    Chromatin loop;    Immunoglobulin gene;    Enhancer;    Topoisomerase II;    (Yeast);   

DOI  :  10.1016/0014-5793(86)81377-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have previously identified a class of DNA sequence elements, termed matrix association regions (MARs), which specifically bind to nuclear matrices in vitro and are believed to be at the bases of chromosomal loops in vivo [1]. Here we demonstrate that nuclear matrices prepared from the yeast Saccharomyces cerevisiae will specifically bind an MAR sequence derived from the mouse kappa light chain immunoglobulin gene. This suggests that both MAR sequences and their binding sites have been strongly evolutionarily conserved.

【 授权许可】

Unknown