Pecularities of immunoglobulin gene structures as a basis for somatic mutation emergence

FEBS Letters

Rogozin, I.B.¹  Solovyov, V.V.¹  Kolchanov, N.A.¹ 

[1] Institute of Cytology and Genetics, USSR Academy of Sciences, Siberian Department, Novosibirsk 630090, USSR

关键词: Somatic mutation;    Immunoglobulin gene;    DNA repeat;    Mismatch repair;   

DOI  :  10.1016/0014-5793(87)80018-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Using the method of contextual analysis, we have studied the collection of somatic mutations in immunoglobulin genes. It has been found that the emergence of somatic mutations can be based on the reparation of complementarity violations in the heteroduplexes corresponding to complementary palindromes or direct repeats of DNA.

【 授权许可】

Unknown