The addition of whole soy flour to cafeteria diet reduces metabolic risk markers in wistar rats

Lipids in Health and Disease

Hércia Stampini Duarte Martino¹  Sonia Machado Rocha Ribeiro¹  Laércio dos Anjos Benjamin²  Maria Inês de Souza Dantas¹  Ana Cristina Rocha Espeschit¹  Crislaine das Graças de Almeida¹  Gláucia Ferreira Andrade¹ 

[1] Department of Nutrition and Health, CCB-II, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil;Department of Veterinary Medicine, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil

关键词: Lipid peroxidation;    Intestinal histomorphometry;    Functional foods;    Cafeteria diet;    Soybean;   

Others  :  829644
DOI  :  10.1186/1476-511X-12-145

 received in 2013-08-15, accepted in 2013-10-08,  发布年份 2013

【 摘 要 】

Background

Soybean is termed a functional food because it contains bioactive compounds. However, its effects are not well known under unbalanced diet conditions. This work is aimed at evaluating the effect of adding whole soy flour to a cafeteria diet on intestinal histomorphometry, metabolic risk and toxicity markers in rats.

Methods

In this study, 30 male adult Wistar rats were used, distributed among three groups (n = 10): AIN-93 M diet, cafeteria diet (CAF) and cafeteria diet with soy flour (CAFS), for 56 days. The following parameters were measured: food intake; weight gain; serum concentrations of triglycerides, total cholesterol, HDL-c, glycated hemoglobin (HbA1c), aspartate (AST) and alanine (ALT) aminotransferases and Thiobarbituric Acid Reactive Substances (TBARS); humidity and lipid fecal content; weight and fat of the liver. The villous height, the crypt depth and the thickness of the duodenal and ileal circular and longitudinal muscle layers of the animals were also measured.

Results

There was a significant reduction in the food intake in the CAF group. The CAFS showed lower serum concentrations of triglycerides and serum TBARS and a lower percentage of hepatic fat, with a corresponding increase in thickness of the intestinal muscle layers. In the CAF group, an increase in the HbA1c, ALT, lipid excretion, liver TBARS and crypt depth, was observed associated with lower HDL-c and villous height. The addition of soy did not promote any change in these parameters.

Conclusions

The inclusion of whole soy flour in a high-fat diet may be helpful in reducing some markers of metabolic risk; however, more studies are required to clarify its effects on unbalanced diets.

【 授权许可】

   
2013 Andrade et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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