Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats

Revista de Nutrição

Danilo Antônio Corrêa Pinto Júnior¹  Patricia Monteiro Seraphim¹ 

[1] ,Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências e Tecnologia de Presidente Prudente Presidente Prudente SP ,Brasil

关键词: Cafeteria diet;    High-fat food;    Insulin resistance;    Obesity;    Dieta de cafeteria;    Alimento hipercalórico;    Resistência à insulina;    Obesidade;   

DOI  :  10.1590/S1415-52732012000300001

来源: SciELO

【 摘 要 】

OBJECTIVE: Obesity is a strong predictor of some kinds of diseases. High intake of high-fat foods contributes significantly to the growth of the obese population globally. The aim of this study was to verify if consumption of a cafeteria diet for fourteen weeks could increase white fat mass, body weight and skeletal muscle mass and promote insulin resistance in male Wistar rats. METHODS: Twenty animals were divided into two groups: control and obese. Both were fed standard chow and water ad libitum. Additionally, a cafeteria diet consisting of bacon, bologna sausage, sandwich cookies and soft drink was given to the obese group. RESULTS: The obese group was significantly heavier (p<0.0001) than controls from the second week until the end of the cafeteria-diet intervention. Absolute and relative fat mass, liver weight and Lee Index increased significantly (p<0.05) in the obese group. Furthermore, the obese group had lower (p<0.05) insulin sensitivity than the control group. CONCLUSION: In conclusion, fourteen weeks of cafeteria diet promoted a progressive increase of fat mass and insulin resistance. Therefore, this is a great and inexpensive diet-induced insulin resistance model.

【 授权许可】

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