Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans

Immunity & Ageing

Sastry Gollapudi²  Sudhanshu Agrawal²  Sudhir Gupta¹ 

[1] Medical Sciences I, C-240, University of California, Irvine, CA, 92697, USA;Programs in Primary Immunodeficiency and Aging, Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA

关键词: B cells;    IL-10;    IL-6;    TNF-α;   

Others  :  815147
DOI  :  10.1186/1742-4933-10-3

 received in 2012-11-30, accepted in 2013-01-13,  发布年份 2013

【 摘 要 】

Aging is associated chronic inflammation and autoimmunity, and increased levels of leptin. Increased levels of leptin are associated with inflammation and autoimmunity. We have recently reported that leptin activates B cells to induce secretion of proinflammatory and anti-inflammatory cytokines. Role of B cells and leptin in inflammation associated with aging has not been explored. In this study we demonstrate that leptin activates and induces significantly greater amount of IL-6, TNF-α, and IL-10 by B cells from aged humans as compared to young controls. This is associated with increased leptin-induced phosphorylation of STAT3 (signal transducer and activator of transcription-3) in B cells from aged humans as compared to young subjects. These data suggest that leptin-induced B cell-derived proinflammatory cytokines may play a role in chronic inflammation associated with human aging.

【 授权许可】

   
2013 Gupta et al.; licensee BioMed Central Ltd.

【 图 表 】

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