Isolation and anti-microbial susceptibility pattern of group B Streptococcus among pregnant women attending antenatal clinics in Ayder Referral Hospital and Mekelle Health Center, Mekelle, Northern Ethiopia

BMC Research Notes

Tsehaye Asmelash¹  Muthupandian Saravanan¹  Mehamud Abdulkadir¹  Haftamu Hailekiros¹  Selam Niguse¹  Gebreselassie Alemseged² 

[1] Department of Medical Microbiology and Immunology, Institute of Biomedical Science, College of Health Sciences, Mekelle University, Mekelle, 1871, Ethiopia;Microbiology Department, Lemlem Karl Hospital, Maichew, Ethiopia

关键词: Antibiotic resistance;    Antimicrobial susceptibility;    Group B Streptococcus;    Vaginal swab;    Antenatal clinic;    Pregnant women;   

Others  :  1229546
DOI  :  10.1186/s13104-015-1475-3

 received in 2015-07-07, accepted in 2015-09-21,  发布年份 2015

【 摘 要 】

Background

Vaginal colonization with group B Streptococcus (GBS) is the predominant risk factor for the development of invasive neonatal GBS diseases and puts newborns at increased risk for morbidity and mortality. This study is aimed to determine the colonization rate and antimicrobial susceptibility pattern of group B Streptococcus among pregnant women.

Methods

Hospital based cross-sectional study was conducted from August to December 2014 at selected health facilities. A total of 139 antenatal clinics attendees, proportionally allocated, were recruited consecutively. Socio-demographic and clinical factors were collected using a structured questionnaire. Vaginal swabs were collected and cultured on Todd Hewitt broth and in 5 % sheep blood agar. Antimicrobial susceptibility test was done using Kirby-Bauer disk diffusion test. Statistical analysis was performed using Pearson’s Chi square test.

Results

Among the 139, 19 (13.7 %) were positive for GBS. All the GBS isolates were susceptible (100 %) to penicillin G, vancomycin, ampicillin, erythromycin and gentamicin. Two of the GBS isolates showed multidrug resistance against norfloxacin and ciprofloxacin. No statistically significant difference was observed for GBS colonization with any independent variables.

Conclusion

Vaginal colonization of GBS for the present study put emphasis on further investigation and accomplishment of routine GBS screening practices. The recovery of resistant strains to antimicrobial agents recommended in cases of penicillin allergic mothers indicates the importance of susceptibility test.

【 授权许可】

   
2015 Alemseged et al.

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