Evaluation of regional antibiograms to monitor antimicrobial resistance in hampton roads, Virginia

Annals of Clinical Microbiology and Antimicrobials

Research

Susette K Var¹  Rouba Hadi¹  Nancy M Khardori¹ 

[1] Department of Internal Medicine, Eastern Virginia Medical School, VA 23507, 825 Fairfax Ave, Hofheimer Hall, Ste 572, Norfolk, USA;

关键词: Antibacterial susceptibility;    Antibiogram;    Antibiotic resistance;    Antibiotic utilization;    Antimicrobial stewardship;    Antimicrobial susceptibility;    Surveillance;   

DOI  :  10.1186/s12941-015-0080-6

 received in 2014-09-09, accepted in 2015-03-18,  发布年份 2015

来源: Springer

【 摘 要 】

We studied recent antibiograms (2010 to 2011) from 12 hospitals in the Hampton Roads area, Virginia, that refer patients to a tertiary-care facility affiliated with Eastern Virginia Medical School. The data was compiled into a regional antibiogram, and sensitivity rates of common isolates from the tertiary-care facility (central) were compared to those of referring hospitals grouped by locale. Staphylococcus aureus was the most common Gram- positive and E. coli the most common Gram- negative organism grown from clinical samples in the area. Overall 53% of S.aureus isolates were resistant to oxacillin. There was a broad scatter of MIC (minimum inhibitory concentration) for vancomycin within the susceptibility range, and MIC of 4 μg/mL was reported in 2012. Penicillin resistance was seen in 50% and erythromycin resistance in 45% of Streptococcus pneumoniae. Vancomycin resistance was seen in 75% of Enterococcus faecium and 2% of Enterococcus faecalis respectively. Acinetobacter baumannii was the most resistant Gram negative organism in the data compiled. Among the Escherichia coli, 26%, 44% and 52%were resistant to Trimethoprim/Sulfamethoxazole ( SXT) ampicillin- sulbactam and ampicillin respectively. We found significant differences in methodology, interpretation and antibiotic panels used by area laboratories. Based on these findings, we are now prospectively following resistance patterns in the tertiary-care facility, sharing data, and creating a consistent approach to antimicrobial susceptibility testing in the region.

【 授权许可】

Unknown   
© Var et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.