Antimicrobial activity and time kill kinetics of Nigerian Honeys on multi-resistant Enteric Bacilli

8th International Biotechnology Conference, Exhibition and Workshop

Akinduti, P.A.^1 ; Oluwadun, A.^2 ; Olugbuyiro, J.A.O.^3 ; Osuagwu, C.S.^4 ; Ejilude, O.^2 ; Onagbesan, K.O.^5 ; Olasehinde, G.I.^1 ; Taiwo, O.S.^1 ; Obafemi, Y.D.^1

Department of Biological Sciences, Covenant University, Ota, Ogun State, Nigeria^1

Department of Medical Microbiology and Parasitology, Olabisi Onabanjo University, Sagamu Campus, Sagamu, Ogun state, Nigeria^2

Department of Chemistry, Covenant University, Otta, Nigeria^3

Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Lagos, Nigeria^4

Biotechnology Centre, Federal University of Agriculture, Nigeria Abeokuta, Nigeria^5

关键词: Anti-microbial activity;    Antibiotic susceptibilities;    Antimicrobial susceptibility;    honey;    Physico;    chemical parameters;    Physico-chemicals;    Phytochemicals;    resistant;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/210/1/012003/pdf
DOI  :  10.1088/1755-1315/210/1/012003

来源: IOP

【 摘 要 】

Antimicrobial activities of some Nigeria honeys were tested on multi-antibiotic resistant enteric bacilli strains (MAREBS) that are becoming dreadful among the populace. Enteric bacilli isolated from fecal samples randomly collected from community populace were biotyped and profiled for antibiotic susceptibility by micro-broth dilution assay. Honey physico-chemical and phyto-chemical metabolites were analysed and tested for antimicrobial susceptibility to MAREBS while its time kill kinetics was evaluated. Significant rate of 31.3% Escherichia coli, Klebsiella oxytoca, (19.5%), Pseudomonas aeruginosa (15.3%) were found with only 62.6% showed significant resistance to cefotaxime (30μg) and 61.6% to ampicillin (10μg). more than 40% showed significant resistance to Cotrimoxazole, ciprofloxacin and tetracycline with MIC ≥16 μg/ml (p10CFU/mL. Amidst global burden of enteric infection with persistence antibiotic resistance, Nigerian honeys showed a reliable bacteriostatic and cidal activity as prospective novel alternative therapy for MAREBS infections.