PINCH is an independent prognostic factor in rectal cancer patients without preoperative radiotherapy - a study in a Swedish rectal cancer trial of preoperative radiotherapy

BMC Cancer

Annica Holmqvist³  Jingfang Gao³  Birgitta Holmlund³  Gunnar Adell³  John Carstensen²  Dianne Langford¹  Xiao-Feng Sun³ 

[1] Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA, USA

[2] Institute of Health and Society, Faculty of Health Sciences, Linköping University, Linköping, Sweden

[3] Department of Medical Oncology, Institute of Clinical and Experimental Medicine, Linköping University, S-58185 Linköping, Sweden

关键词: Immunohistochemistry;    Rectal cancer;    Prognosis;    Radiotherapy;    PINCH;   

Others  :  1080542
DOI  :  10.1186/1471-2407-12-65

 received in 2011-08-26, accepted in 2012-02-10,  发布年份 2012

【 摘 要 】

Background

The clinical significance between particularly interesting new cysteine-histidine rich protein (PINCH) expression and radiotherapy (RT) in tumours is not known. In this study, the expression of PINCH and its relationship to RT, clinical, pathological and biological factors were studied in rectal cancer patients.

Methods

PINCH expression determined by immunohistochemistry was analysed at the invasive margin and inner tumour area in 137 primary rectal adenocarcinomas (72 cases without RT and 65 cases with RT). PINCH expression in colon fibroblast cell line (CCD-18 Co) was determined by western blot.

Results

In patients without RT, strong PINCH expression at the invasive margin of primary tumours was related to worse survival, compared to patients with weak expression, independent of TNM stage and differentiation (P = 0.03). No survival relationship in patients with RT was observed (P = 0.64). Comparing the non-RT with RT subgroup, there was no difference in PINCH expression in primary tumours (invasive margin (P = 0.68)/inner tumour area (P = 0.49). In patients with RT, strong PINCH expression was related to a higher grade of LVD (lymphatic vessel density) (P = 0.01)

Conclusions

PINCH expression at the invasive margin was an independent prognostic factor in patients without RT. RT does not seem to directly affect the PINCH expression.

【 授权许可】

   
2012 Holmqvist et al; BioMed Central Ltd.

【 图 表 】

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