PINCH is an independent prognostic factor in rectal cancer patients without preoperative radiotherapy - a study in a Swedish rectal cancer trial of preoperative radiotherapy

BMC Cancer

Research Article

Jingfang Gao¹  Birgitta Holmlund¹  Gunnar Adell¹  Xiao-Feng Sun¹  Annica Holmqvist¹  Dianne Langford²  John Carstensen³ 

[1] Department of Medical Oncology, Institute of Clinical and Experimental Medicine, Linköping University, S-58185, Linköping, Sweden;Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA, USA;Institute of Health and Society, Faculty of Health Sciences, Linköping University, Linköping, Sweden;

关键词: PINCH;    Radiotherapy;    Prognosis;    Rectal cancer;    Immunohistochemistry;   

DOI  :  10.1186/1471-2407-12-65

 received in 2011-08-26, accepted in 2012-02-10,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe clinical significance between particularly interesting new cysteine-histidine rich protein (PINCH) expression and radiotherapy (RT) in tumours is not known. In this study, the expression of PINCH and its relationship to RT, clinical, pathological and biological factors were studied in rectal cancer patients.MethodsPINCH expression determined by immunohistochemistry was analysed at the invasive margin and inner tumour area in 137 primary rectal adenocarcinomas (72 cases without RT and 65 cases with RT). PINCH expression in colon fibroblast cell line (CCD-18 Co) was determined by western blot.ResultsIn patients without RT, strong PINCH expression at the invasive margin of primary tumours was related to worse survival, compared to patients with weak expression, independent of TNM stage and differentiation (P = 0.03). No survival relationship in patients with RT was observed (P = 0.64). Comparing the non-RT with RT subgroup, there was no difference in PINCH expression in primary tumours (invasive margin (P = 0.68)/inner tumour area (P = 0.49). In patients with RT, strong PINCH expression was related to a higher grade of LVD (lymphatic vessel density) (P = 0.01)ConclusionsPINCH expression at the invasive margin was an independent prognostic factor in patients without RT. RT does not seem to directly affect the PINCH expression.

【 授权许可】

CC BY   
© Holmqvist et al; BioMed Central Ltd. 2012