Cell type specificity of female lung cancer associated with sulfur dioxide from air pollutants in Taiwan: An ecological study

BMC Public Health

Yung-Po Liaw⁴  Chien-Chang Ho⁵  Chia-Chi Lung⁴  Cheng-Hsiu Lai⁶  Jing-Yang Huang¹  Shih-Yung Su¹  Yi-Chia Huang²  Ching-Yu Tseng³ 

[1] Department of Public Health and Institute of Public Health, Chung Shan Medical University, Chien-Kuo N. Road, Taichung City 40201, Taiwan, R.O.C;School of Nutrition, Chung Shan Medical University, Taichung City 40201, Taiwan, R.O.C;Department of Physical Education, Fu Jen Catholic University, New Taipei City 24205, Taiwan, R.O.C;Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan, R.O.C;Doctoral Program in Physical Education, Taipei Physical Education College, Taipei City 11153, Taiwan, R.O.C;Department and Graduate Institute of Physical Education and Health, Taipei Physical Education College, Taipei City 11153, Taiwan, R.O.C

关键词: Age-standardized incidence rate;    Sulfur dioxide;    Adenocarcinoma;    Squamous cell carcinoma;    Lung cancer;   

Others  :  1163970
DOI  :  10.1186/1471-2458-12-4

 received in 2011-07-30, accepted in 2012-01-04,  发布年份 2012

【 摘 要 】

Background

Many studies have examined the association between air pollutants (including sulfur dioxide [SO₂], carbon monoxide [CO], nitrogen dioxide [NO₂], nitric oxide [NO], ozone [O₃], and particulate matter < 10 μm [PM₁₀]) and lung cancer. However, data from previous studies on pathological cell types were limited, especially for SO₂ exposure. We aimed to explore the association between SO₂ exposure from outdoor air pollutants and female lung cancer incidence by cell type specificity.

Methods

We conducted an ecological study and calculated annual average concentration of 6 air pollutants (SO₂, CO, NO₂, NO, O₃, and PM₁₀) using data from Taiwan Environmental Protection Administration air quality monitoring stations. The Poisson regression models were used to evaluate the association between SO₂ and age-standardized incidence rate of female lung cancer by two major pathological types (adenocarcinoma [AC] and squamous cell carcinoma [SCC]). In order to understand whether there is a dose-response relationship between SO₂ and two major pathological types, we analyzed 4 levels of exposure based on quartiles of concentration of SO₂.

Results

The Poisson regression results showed that with the first quartile of SO₂ concentration as the baseline, the relative risks for AC/SCC type cancer among females were 1.20 (95% confidence interval [CI], 1.04-1.37)/1.39 (95% CI, 0.96-2.01) for the second, 1.22 (95% CI, 1.04-1.43)/1.58 (95% CI, 1.06-2.37) for the third, and 1.27 (95% CI, 1.06-1.52)/1.80 (95% CI, 1.15-2.84) for the fourth quartile of SO₂ concentration. The tests for trend were statistically significant for both AC and SCC at P = 0.0272 and 0.0145, respectively.

Conclusion

The current study suggests that SO₂ exposure as an air pollutant may increase female lung cancer incidence and the associations with female lung cancer is much stronger for SCC than for AC. The findings of this study warrant further investigation on the role of SO₂ in the etiology of SCC.

【 授权许可】

   
2011 Tseng et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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