Cell type specificity of female lung cancer associated with sulfur dioxide from air pollutants in Taiwan: An ecological study

BMC Public Health

Research Article

Cheng-Hsiu Lai¹  Jing-Yang Huang²  Shih-Yung Su²  Chia-Chi Lung³  Yung-Po Liaw³  Chien-Chang Ho⁴  Ching-Yu Tseng⁵  Yi-Chia Huang⁶ 

[1] Department and Graduate Institute of Physical Education and Health, Taipei Physical Education College, 11153, Taipei City, R.O.C, Taiwan;Department of Public Health and Institute of Public Health, Chung Shan Medical University, Chien-Kuo N. Road, 40201, Taichung City, R.O.C, Taiwan;Department of Public Health and Institute of Public Health, Chung Shan Medical University, Chien-Kuo N. Road, 40201, Taichung City, R.O.C, Taiwan;Department of Family and Community Medicine, Chung Shan Medical University Hospital, 40201, Taichung City, R.O.C, Taiwan;Doctoral Program in Physical Education, Taipei Physical Education College, 11153, Taipei City, R.O.C, Taiwan;Doctoral Program in Physical Education, Taipei Physical Education College, 11153, Taipei City, R.O.C, Taiwan;Department of Physical Education, Fu Jen Catholic University, 24205, New Taipei City, R.O.C, Taiwan;School of Nutrition, Chung Shan Medical University, 40201, Taichung City, R.O.C, Taiwan;

关键词: Lung cancer;    Squamous cell carcinoma;    Adenocarcinoma;    Sulfur dioxide;    Age-standardized incidence rate;   

DOI  :  10.1186/1471-2458-12-4

 received in 2011-07-30, accepted in 2012-01-04,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundMany studies have examined the association between air pollutants (including sulfur dioxide [SO2], carbon monoxide [CO], nitrogen dioxide [NO2], nitric oxide [NO], ozone [O3], and particulate matter < 10 μm [PM10]) and lung cancer. However, data from previous studies on pathological cell types were limited, especially for SO2 exposure. We aimed to explore the association between SO2 exposure from outdoor air pollutants and female lung cancer incidence by cell type specificity.MethodsWe conducted an ecological study and calculated annual average concentration of 6 air pollutants (SO2, CO, NO2, NO, O3, and PM10) using data from Taiwan Environmental Protection Administration air quality monitoring stations. The Poisson regression models were used to evaluate the association between SO2 and age-standardized incidence rate of female lung cancer by two major pathological types (adenocarcinoma [AC] and squamous cell carcinoma [SCC]). In order to understand whether there is a dose-response relationship between SO2 and two major pathological types, we analyzed 4 levels of exposure based on quartiles of concentration of SO2.ResultsThe Poisson regression results showed that with the first quartile of SO2 concentration as the baseline, the relative risks for AC/SCC type cancer among females were 1.20 (95% confidence interval [CI], 1.04-1.37)/1.39 (95% CI, 0.96-2.01) for the second, 1.22 (95% CI, 1.04-1.43)/1.58 (95% CI, 1.06-2.37) for the third, and 1.27 (95% CI, 1.06-1.52)/1.80 (95% CI, 1.15-2.84) for the fourth quartile of SO2 concentration. The tests for trend were statistically significant for both AC and SCC at P = 0.0272 and 0.0145, respectively.ConclusionThe current study suggests that SO2 exposure as an air pollutant may increase female lung cancer incidence and the associations with female lung cancer is much stronger for SCC than for AC. The findings of this study warrant further investigation on the role of SO2 in the etiology of SCC.

【 授权许可】

Unknown   
© Tseng et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.