Cell-type specificity of lung cancer associated with low-dose soil heavy metal contamination in Taiwan: An ecological study

BMC Public Health

Yung-Po Liaw⁷  Shih-Chang Chen³  Shih-Yung Su²  Pei-Chieh Ko²  Yi-Hua Sun¹  Chien-Chang Ho⁶  Chih-Lung Wu⁴  Chia-Chi Lung⁷  Jing-Yang Huang²  Hsien-Hung Huang⁵ 

[1] Department of Dentistry, Chung Shan Medical University, Taichung City, 40201, Taiwan;Department of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Road, Taichung City, 40201, Taiwan;Department of Leisure Industry and Health Promotion, National Ilan University, Yilan Country, 26047, Taiwan;Department of Orthopaedic Surgery, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan;Jen-Ai Hospital, Taichung City, 41265, Taiwan;Department of Health and Leisure Management, Yuanpei University, Hsinchu City, 30015, Taiwan;Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung City, 40201, Taiwan

关键词: Age-standardized incidence rate;    Soil heavy metal;    Squamous cell carcinoma;    Adenocarcinoma;    Lung cancer;   

Others  :  1162351
DOI  :  10.1186/1471-2458-13-330

 received in 2012-04-27, accepted in 2013-03-25,  发布年份 2013

【 摘 要 】

Background

Numerous studies have examined the association between heavy metal contamination (including arsenic [As], cadmium [Cd], chromium [Cr], copper [Cu], mercury [Hg], nickel [Ni], lead [Pb], and zinc [Zn]) and lung cancer. However, data from previous studies on pathological cell types are limited, particularly regarding exposure to low-dose soil heavy metal contamination. The purpose of this study was to explore the association between soil heavy metal contamination and lung cancer incidence by specific cell type in Taiwan.

Methods

We conducted an ecological study and calculated the annual averages of eight soil heavy metals (i.e., As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn) by using data from the Taiwan Environmental Protection Administration from1982 to 1986. The age-standardized incidence rates of lung cancer according to two major pathological types (adenocarcinoma [AC] and squamous cell carcinoma [SCC]) were obtained from the National Cancer Registry Program conducted in Taiwan from 2001 to 2005. A geographical information system was used to plot the maps of soil heavy metal concentration and lung cancer incidence rates. Poisson regression models were used to obtain the adjusted relative ratios (RR) and 95% confidence intervals (CI) for the lung cancer incidence associated with soil heavy metals.

Results

For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose–response relationship. However, for lung AC, only Cu and Ni had a significant dose–response relationship. As for females, those achieving a statistically significant dose–response relationship for the trend test were Cr (P = 0.02), Ni (P = 0.02), and Zn (P= 0.02) for lung SCC, and Cu (P < 0.01) and Zn (P = 0.02) for lung AC.

Conclusion

The current study suggests that a dose–response relationship exists between low-dose soil heavy metal concentration and lung cancer occurrence by specific cell-type; however, the relevant mechanism should be explored further.

【 授权许可】

   
2013 Huang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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