Whey peptide-based enteral diet attenuated elastase-induced emphysema with increase in short chain fatty acids in mice

BMC Pulmonary Medicine

Hiroshi Kimura¹  Kaoru Hamada¹  Masanori Yoshikawa¹  Atsuhiro Nakamura¹  Yasue Nishii⁴  Yoshifumi Yamamoto¹  Taketo Yamaji²  Kazuo Dairiki²  Kaoru Kubo³  Koichi Tomoda¹ 

[1] Second Department of Internal Medicine, Nara Medical University, Kashihara, 634-8521, Nara, Japan;Food Science Research Labs., R&D Div., Meiji Co. Ltd., Odawara, 250-0862, Kanagawa, Japan;Laboratory Animal Research Center, Nara Medical University, Kashihara, 634-8521, Nara, Japan;Faculty of Health Science, Kio University, Nara, 635-0832, Japan

关键词: Cecum;    Short chain fatty acids;    Chronic obstructive pulmonary disease;    C57BL/6 mice;    Whey peptide;    Emphysema;    Elastase;   

Others  :  1216165
DOI  :  10.1186/s12890-015-0059-2

 received in 2015-04-07, accepted in 2015-05-18,  发布年份 2015

【 摘 要 】

Background

Systemic inflammation is present in chronic obstructive pulmonary disease (COPD). A whey peptide-based enteral diet reduce inflammation in patients with COPD, but its effect on COPD development has not been determined. On the other hand, it is known that short chain fatty acids (SCFAs), which are produced by micro-flora in the gut, attenuates bronchial asthma in mice model.

Methods

Mice with elastase-induced emphysema were fed with 1 of 3 diets (control diet, whey peptide-based enteral diet, or standard enteral diet) to determine the effects of whey peptide-based enteral diet on emphysema and on cecal SCFAs.

Results

The whey peptide-based enteral diet group exhibited fewer emphysematous changes; significantly lower total cell counts in bronchoalveolar lavage fluid (BALF); and significantly higher cecal SCFA levels than either the control or standard enteral diet groups. The total cell count was inversely correlated with total cecal SCFA levels in these three diet groups.

Conclusions

The whey peptide-based enteral diet attenuates elastase-induced emphysema through the suppression of inflammation in the lung. This may be related to the increase in cecal SCFA.

【 授权许可】

   
2015 Tomoda et al.

【 图 表 】

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