Long-Term Effects of Stem Cells on Total-Body Irradiated Mice

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Vyalkina, M.V.^1 ; Alchinova, I.B.^1 ; Yakovenko, E.N.^1 ; Medvedeva, Yu.S.^1 ; Saburina, I.N.^1 ; Karganov, M.Yu.^1

Institute of General Pathology and Pathophysiology, Baltiyskaya str., 8, Moscow

125315, Russia^1

关键词: C57BL/6 mice;    Correlation spectroscopy;    Experimental groups;    General trends;    Histological examination;    Long-term effects;    Multipotent mesenchymal stromal cells;    Sublethal dose;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012015/pdf
DOI  :  10.1088/1742-6596/784/1/012015

来源: IOP

【 摘 要 】

C57Bl/6 mice were exposed to γ-radiation in a sublethal dose of 7.5 Gy. In 3 hours injection 106/mouse of bone marrow multipotent mesenchymal stromal cells stem cells intravenously to experimental group was done. Methods used: body weight measurement, open field behavior, subfraction composition of blood serum (laser correlation spectroscopy, LCS), histological examination of the spleen, liver, and pancreas, count of T and B cells, white blood formula. After 1.5 and 3 months the general trend towards intermediate position of the parameters observed in the experimental between those in intact and irradiated controls attests to partial protective/restorative effects of the injected cells.