Calcification of coronary arteries and abdominal aorta in relation to traditional and novel risk factors of atherosclerosis in hemodialysis patients

BMC Nephrology

Jerzy Chudek⁴  Andrzej Więcek¹  Magdalena Olszanecka-Glinianowicz³  Agata Kujawa-Szewieczek¹  Katarzyna Wyskida¹  Rafał Ficek¹  Beata Czerwieńska¹  Przemysław Pencak² 

[1] Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland;Department of Radiology, Medical University Hospital SPSK-M, Katowice, Poland;Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland;Pathophysiology Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland

关键词: Hemodialysis;    Risk factors;    Atherosclerosis;   

Others  :  1083028
DOI  :  10.1186/1471-2369-14-10

 received in 2012-11-21, accepted in 2013-01-08,  发布年份 2013

【 摘 要 】

Background

Process of accelerated atherosclerosis specific for uremia increases cardiovascular risk in patients with chronic kidney disease (CKD) and may be influenced by the different structure of arteries. The study assesses the influence of traditional and novel risk factors on calcification of coronary arteries (CAC) and abdominal aorta (AAC) in hemodialysis patients (HD).

Methods

CAC and AAC were assessed by CT in 104 prevalent adult HD and 14 apparently healthy subjects with normal kidney function (control group). Mineral metabolism parameters, plasma levels of FGF-23, MGP, osteoprotegerin, osteopontin, fetuin-A, CRP, IL-6 and TNF-α were measured.

Results

CAC and AAC (calcification score ≥ 1) were found in 76 (73.1%) and 83 (79.8%) HD respectively, more frequent than in the control group. In 7 HD with AAC no CAC were detected. The frequency and severity of calcifications increased with age. Both CAC and AAC were more frequently detected in diabetics (OR = 17.37 and 13.00, respectively). CAC score was significantly greater in males. CAC and AAC scores were correlated significantly with pack-years of smoking and plasma osteoprotegrin levels. However the independent contribution of plasma osteoprotegerin levels was not confirmed in multiple regression analysis. Age (OR = 1.13) and hemodialysis vintage (OR = 1.14) were the independent risk factor favoring the occurrence of CAC; while age (OR = 1.20) was the only predictor of AAC occurrence in HD.

Conclusions

1. AAC precedes the occurrence of CAC in HD patients. 2. The exposition to uremic milieu and systemic chronic microinflammation has more deteriorative effect on the CAC than the AAC.

【 授权许可】

   
2013 Pencak et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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