Arsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India

BMC Public Health

Ashok K Giri⁷  J Christopher States⁴  Apurba K Bandyopadhyay⁷  Papiya Majumder²  Saptarshi Banerjee⁵  Santanu Basu³  Tanmoy J Sau¹  Nilendu Sarma⁶  Niladri S Majumder⁷  Nilanjana Banerjee⁷  Debmita Chatterjee⁷  Somnath Paul⁷  Nandana Das⁷ 

[1] Department of Medicine, Calcutta National Medical College, Kolkata, 700 017, West Bengal, India;Tata Main Hospital, Jamshedpur, 831001, Jharkhand, India;Department of General Medicine, Sri Aurobindo Seva Kendra, Kolkata, 700068, West Bengal, India;Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40209, USA;Regional Institute of Opthalmology, Calcutta Medical College, Kolkata, 700073, West Bengal, India;Sir Nil Ratan Sircar Medical College and Hospital, Kolkata, 700 014, India;Molecular and Human Genetics Division, CSIR- Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata, 700 032, India

关键词: Cytokines;    Liver function tests;    Antinuclear antibody;    Arsenic;   

Others  :  1163313
DOI  :  10.1186/1471-2458-12-639

 received in 2012-04-02, accepted in 2012-07-24,  发布年份 2012

【 摘 要 】

Background

Arsenic is a natural drinking water contaminant affecting 26 million people in West Bengal, India. Chronic arsenic exposure causes cancer, cardiovascular disease, liver disease, neuropathies and ocular diseases. The aims of the present study were to assess bioindicators of hepatocellular injury as indicated by the levels of liver enzymes, to determine the auto immune status, as indicated by the amounts of anti-nuclear antibodies (ANA) and anti-dsDNA antibodies in their serum, and to predict cardiovascular risk in the arsenic exposed population.

Methods

Effect of chronic arsenic exposure on liver was determined by liver function tests. Autoimmune status was measured by measuring ANA and anti-dsDNA in serum. Inflammatory cytokines associated with increased cardiovascular disease risk, IL6, IL8 and MCP-1 were determined.

Results

Our results indicated that serum levels of bilirubin, alanine transaminase, aspartate transaminase, alkaline phosphatase and ANA were increased in the arsenic exposed population. Serum levels of IL6 and IL8 also increased in the arsenic exposed group.

Conclusions

Chronic arsenic exposure causes liver injury, increases the serum levels of autoimmune markers and imparts increased cardiovascular risk.

【 授权许可】

   
2012 Das et al.; licensee BioMed Central Ltd.

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