Arsenic exposure through drinking water increases the risk of liver and cardiovascular diseases in the population of West Bengal, India

BMC Public Health

Research Article

Santanu Basu¹  Tanmoy J Sau²  J Christopher States³  Ashok K Giri⁴  Nandana Das⁴  Debmita Chatterjee⁴  Niladri S Majumder⁴  Nilanjana Banerjee⁴  Somnath Paul⁴  Apurba K Bandyopadhyay⁴  Saptarshi Banerjee⁵  Nilendu Sarma⁶  Papiya Majumder⁷ 

[1] Department of General Medicine, Sri Aurobindo Seva Kendra, 700068, Kolkata, West Bengal, India;Department of Medicine, Calcutta National Medical College, 700 017, Kolkata, West Bengal, India;Department of Pharmacology and Toxicology, University of Louisville, 40209, Louisville, KY, USA;Molecular and Human Genetics Division, CSIR- Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, 700 032, Kolkata, India;Regional Institute of Opthalmology, Calcutta Medical College, 700073, Kolkata, West Bengal, India;Sir Nil Ratan Sircar Medical College and Hospital, 700 014, Kolkata, India;Tata Main Hospital, 831001, Jamshedpur, Jharkhand, India;

关键词: Arsenic;    Antinuclear antibody;    Liver function tests;    Cytokines;   

DOI  :  10.1186/1471-2458-12-639

 received in 2012-04-02, accepted in 2012-07-24,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundArsenic is a natural drinking water contaminant affecting 26 million people in West Bengal, India. Chronic arsenic exposure causes cancer, cardiovascular disease, liver disease, neuropathies and ocular diseases. The aims of the present study were to assess bioindicators of hepatocellular injury as indicated by the levels of liver enzymes, to determine the auto immune status, as indicated by the amounts of anti-nuclear antibodies (ANA) and anti-dsDNA antibodies in their serum, and to predict cardiovascular risk in the arsenic exposed population.MethodsEffect of chronic arsenic exposure on liver was determined by liver function tests. Autoimmune status was measured by measuring ANA and anti-dsDNA in serum. Inflammatory cytokines associated with increased cardiovascular disease risk, IL6, IL8 and MCP-1 were determined.ResultsOur results indicated that serum levels of bilirubin, alanine transaminase, aspartate transaminase, alkaline phosphatase and ANA were increased in the arsenic exposed population. Serum levels of IL6 and IL8 also increased in the arsenic exposed group.ConclusionsChronic arsenic exposure causes liver injury, increases the serum levels of autoimmune markers and imparts increased cardiovascular risk.

【 授权许可】

Unknown   
© Das et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.