Influence of multiple APOE genetic variants on cognitive function in a cohort of older men – results from the Normative Aging Study

BMC Psychiatry

Andrea A Baccarelli⁵  Joel Schwartz⁵  Luis A Herrera²  Marco Sanchez-Guerra⁷  Jia Zhong⁷  Pantel Vokonas³  Avron Spiro III³  Lifang Hou⁶  Marc G Weisskopf⁵  David G Cox¹  Melinda C Power⁴  Elena Colicino⁵  Diddier Prada² 

[1] Centre Léon Bérard, Pole de Recherche Translationnelle, Lyon F-69008, France;Instituto Nacional de Cancerología – Instituto de Investigaciones Biomédicas, Unidad de Investigación Biomédica en Cáncer, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico;Boston University School of Public Health, 715 Albany Street, Boston 02118, MA, USA;Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore 21205, MD, USA;Department of Epidemiology, Harvard School of Public Health, 665 Huntington Ave, Boston 02115, MA, USA;Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 420 East Superior St, Chicago 60611, IL, USA;Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston 02115, MA, USA

关键词: Genetic variants;    Aging;    Cognitive decline;    Haplotypes;    Alleles;    Epsilon;    APOE;   

Others  :  1123433
DOI  :  10.1186/s12888-014-0223-x

 received in 2014-04-20, accepted in 2014-07-23,  发布年份 2014

【 摘 要 】

Background

APOE is the biomarker with the greatest known influence on cognitive function; however, the effect of complex haplotypes involving polymorphisms rs449647, rs405509, rs440446, rs429358 and rs7412 has never been studied in older populations.

Methods

We evaluated APOE polymorphisms using multiplex PCR for genotyping and Mini-Mental State Examination (MMSE) to evaluate cognitive function in 819 individuals from VA Normative Aging Study.

Results

Combinatorial analysis of all polymorphisms and individual analysis of polymorphisms rs449647, rs405509, rs440446 and rs7412 did not show any association with cognitive performance. Polymorphism rs429358 was associated with better cognitive performance (odds of MMSE ≤ 25 = 0.63, 95% CI 0.42-0.95; p = 0.03) in the oldest subsample (5^th quintile of age) (odds of MMSE ≤ 25 = 0.34; 95% CI 0.13-0.86; p = 0.02). APOE allele ε4 was also associated with better cognitive performance (odds of MMSE ≤ 25 = 0.61, 95% CI 0.40-0.94; p = 0.02), also in the oldest subsample (odds of MMSE ≤ 25 = 0.35, 95% CI 0.14-0.90; p = 0.03).

Conclusions

These results suggest a beneficial effect of polymorphism rs429358 in the oldest men.

【 授权许可】

   
2014 Prada et al., licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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