Kale supplementation up-regulates HSP70 and suppresses cognitive decline in a mouse model of accelerated senescence

Journal of Functional Foods

Shuichi Yanai¹  Yuki Uchibori²  Shigeru Katayama²  Soichiro Nakamura²  Hidefumi Makabe²  Shoko Kushimoto² 

[1] Aging Neuroscience Research Team, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo 173-0015, Japan;Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan;

关键词: Aging;    Cognitive decline;    Kale;    HSP70;    SAMP8;   

DOI  :  

来源: DOAJ

【 摘 要 】

Dietary interventions have been proposed as an effective way to prevent age-related senescence. Here, we investigated the ability of kale juice (KJ) dietary supplementation to delay cognitive decline in the senescence-accelerated mouse prone 8 (SAMP8) mouse. SAMP8 mice were fed a diet containing 0.8% (w/w) KJ or a control diet for 16 weeks, and cognitive performance was examined using the Morris water maze. KJ administration improved spatial and leaning memory as well as suppressed levels of serum 8-hydroxy-2′-deoxyguanosine and brain malondialdehyde with respect to the control group. Furthermore, the KJ-fed group showed a significant increase in the gene transcription and protein expression of heat shock protein 70 (HSP70). 1-Sinapoyl-2-feruloyl gentiobiose was identified as one of the active components of KJ affecting HSP70 expression. These findings suggest that dietary kale supplementation can suppress cognitive decline and age-related oxidative damage through the activation of HSP70 in SAMP8 mice.

【 授权许可】

Unknown