Structural brain abnormalities in cervical dystonia

BMC Neuroscience

Julian Grosskreutz⁴  Albrecht Günther²  Reinhard Dengler³  Martin H Bokemeyer⁵  Bernadette Köhler³  Thomas Peschel¹  Tino Prell⁴ 

[1] Department of Psychiatry and Psychotherapy, Medical School Hannover, Carl-Neuberg-Strasse 1, 80625 Hannover, Germany;Center for Sepsis Control and Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany;Department of Neurology and Clinical Neurophysiology, Medical School Hannover, Carl-Neuberg-Str.1, 30625 Hannover, Germany;Hans-Berger Department of Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany;Department of Neuroradiology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany

关键词: Dorsolateral prefrontal cortex;    Basal ganglia;    Visual system;   

Others  :  1139996
DOI  :  10.1186/1471-2202-14-123

 received in 2013-06-24, accepted in 2013-10-09,  发布年份 2013

【 摘 要 】

Background

Idiopathic cervical dystonia is characterized by involuntary spasms, tremors or jerks. It is not restricted to a disturbance in the basal ganglia system because non-conventional voxel-based MRI morphometry (VBM) and diffusion tensor imaging (DTI) have detected numerous regional changes in the brains of patients.

In this study scans of 24 patients with cervical dystonia and 24 age-and sex-matched controls were analysed using VBM, DTI and magnetization transfer imaging (MTI) using a voxel-based approach and a region-of-interest analysis. Results were correlated with UDRS, TWSTRS and disease duration.

Results

We found structural alterations in the basal ganglia; thalamus; motor cortex; premotor cortex; frontal, temporal and parietal cortices; visual system; cerebellum and brainstem of the patients with dystonia.

Conclusions

Cervical dystonia is a multisystem disease involving several networks such as the motor, sensory and visual systems.

【 授权许可】

   
2013 Prell et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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