Prefrontal dysfunction in pediatric Tourette’s disorder as measured by near-infrared spectroscopy

BMC Psychiatry

Toshifumi Kishimoto²  Hideki Negoro¹  Shohei Tanaka²  Naoko Kishimoto²  Hiroki Matsuura⁵  Mitsuhiro Uratani³  Yoko Nakanishi²  Junzo Iida⁴  Toyosaku Ota²  Kazuhiko Yamamuro² 

[1] Department of Education, Nara University of Education, Nara, Japan;Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijyou-cho, Kashihara, Nara 634-8522, Japan;Department of Psychiatry, Nara Prefectural General Rehabilitation Center, Shiki, Nara, Japan;Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Nara, Japan;Department of Psychiatry, Tenri Hospital, Tenri, Nara, Japan

关键词: Dorsolateral prefrontal cortex;    Tics;    The Stroop Color-Word Task;    Tourette’s disorder;    Near-infrared spectroscopy;   

Others  :  1178981
DOI  :  10.1186/s12888-015-0472-3

 received in 2014-08-26, accepted in 2015-04-17,  发布年份 2015

【 摘 要 】

Background

Tourette’s disorder (TD) is a chronic childhood-onset disorder characterized by the presence of multiple motor and vocal tics. Despite strong evidence that the pathophysiology of TD involves structural and functional disturbances of the basal ganglia and cortical frontal areas, in vivo imaging studies have produced conflicting results. Recent developments in near-infrared spectroscopy (NIRS) technology have enabled noninvasive assessment of brain function in people with psychiatric disorders.

Methods

We asked 10 individuals with pediatric TD and 10 healthy controls who were age- and sex- matched to perform the Stroop color-word task during NIRS. We used prefrontal probes and a 24-channel NIRS machine to measure the relative concentrations of oxyhemoglobin (oxy-Hb) every 0.1 s during the task.

Results

We found that oxy-Hb changes in the prefrontal cortex were significantly smaller in the TD group compared with the control group, especially in the left dorsolateral prefrontal cortex.

Conclusions

Our data suggest that individuals with pediatric TD have a reduced prefrontal hemodynamic response as measured by NIRS.

【 授权许可】

   
2015 Yamamuro et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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