Prefrontal dysfunction in pediatric Tourette’s disorder as measured by near-infrared spectroscopy

BMC Psychiatry

Research Article

Hideki Negoro¹  Toshifumi Kishimoto²  Yoko Nakanishi²  Kazuhiko Yamamuro²  Shohei Tanaka²  Toyosaku Ota²  Naoko Kishimoto²  Mitsuhiro Uratani³  Hiroki Matsuura⁴  Junzo Iida⁵ 

[1] Department of Education, Nara University of Education, Nara, Japan;Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijyou-cho, Kashihara, 634-8522, Nara, Japan;Department of Psychiatry, Nara Prefectural General Rehabilitation Center, Shiki, Nara, Japan;Department of Psychiatry, Tenri Hospital, Tenri, Nara, Japan;Faculty of Nursing, Nara Medical University School of Medicine, Kashihara, Nara, Japan;

关键词: Near-infrared spectroscopy;    Tourette’s disorder;    The Stroop Color-Word Task;    Tics;    Dorsolateral prefrontal cortex;   

DOI  :  10.1186/s12888-015-0472-3

 received in 2014-08-26, accepted in 2015-04-17,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundTourette’s disorder (TD) is a chronic childhood-onset disorder characterized by the presence of multiple motor and vocal tics. Despite strong evidence that the pathophysiology of TD involves structural and functional disturbances of the basal ganglia and cortical frontal areas, in vivo imaging studies have produced conflicting results. Recent developments in near-infrared spectroscopy (NIRS) technology have enabled noninvasive assessment of brain function in people with psychiatric disorders.MethodsWe asked 10 individuals with pediatric TD and 10 healthy controls who were age- and sex- matched to perform the Stroop color-word task during NIRS. We used prefrontal probes and a 24-channel NIRS machine to measure the relative concentrations of oxyhemoglobin (oxy-Hb) every 0.1 s during the task.ResultsWe found that oxy-Hb changes in the prefrontal cortex were significantly smaller in the TD group compared with the control group, especially in the left dorsolateral prefrontal cortex.ConclusionsOur data suggest that individuals with pediatric TD have a reduced prefrontal hemodynamic response as measured by NIRS.

【 授权许可】

Unknown   
© Yamamuro et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.