期刊论文详细信息
BMC Complementary and Alternative Medicine
A pilot controlled trial of a combination of dense cranial electroacupuncture stimulation and body acupuncture for post-stroke depression
Zhang-Jin Zhang4  Vivian T Wong2  Eric Ziea2  Kevin W Y Tsang5  Kei-Pui Leung5  Kwok-Pui Leung3  Leonard S W Li3  Mandy P M Fung1  Hobby Cheung1  Xiao-Chun Yu6  Roger M K Ng7  Ben H B Hung4  Sui-Cheung Man4 
[1] Department of Rehabilitation, Kowloon Hospital, Hong Kong, China;Chinese Medicine Department, Hospital Authority, Hong Kong, China;Rehabilitation Unit, Tung Wah Hospital, Hong Kong, China;The School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China;Department of Medicine and Rehabilitation, Tung Wah Eastern Hospital, Hong Kong, China;Institute of Acupuncture, China Academy of Chinese Medical Sciences, Dongchen District, Beijing 100700, China;Department of Psychiatry, Kowloon Hospital, Hong Kong, China
关键词: Clinical trial;    DCEAS;    Dense cranial electroacupuncture stimulation;    Rehabilitation;    Post-stroke depression;    Acupuncture;   
Others  :  1087260
DOI  :  10.1186/1472-6882-14-255
 received in 2014-01-10, accepted in 2014-07-14,  发布年份 2014
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【 摘 要 】

Background

Our previous studies have demonstrated the treatment benefits of dense cranial electroacupuncture stimulation (DCEAS), a novel brain stimulation therapy in patients with major depression, postpartum depression and obsessive-compulsive disorder. The purpose of the present study was to further evaluate the effectiveness of DCEAS combined with body acupuncture and selective serotonin reuptake inhibitors (SSRIs) in patients with post-stroke depression (PSD).

Methods

In a single-blind, randomized controlled trial, 43 patients with PSD were randomly assigned to 12 sessions of DCEAS plus SSRI plus body electroacupuncture (n = 23), or sham (non-invasive cranial electroacupuncture, n-CEA) plus SSRI plus body electroacupuncture (n = 20) for 3 sessions per week over 4 weeks. Treatment outcomes were measured using the 17-item Hamilton Depression Rating Scale (HAMD-17), the Clinical Global Impression - Severity scale (CGI-S) and Barthel Index (BI), a measure used to evaluate movement ability associated with daily self-caring activity.

Results

DCEAS produced a significantly greater reduction of both HAMD-17 and CGI-S as early as week 1 and CGI-S at endpoint compared to n-CEA, but subjects of n-CEA group exhibited a significantly greater improvement on BI at week 4 than DCEAS. Incidence of adverse events was not different in the two groups.

Conclusions

These results indicate that DCEAS could be effective in reducing stroke patients’ depressive symptoms. Superficial electrical stimulation in n-CEA group may be beneficial in improving movement disability of stroke patients. A combination of DCEAS and body acupuncture can be considered a treatment option for neuropsychiatric sequelae of stroke.

Trial registration

http://www.clinicaltrials.gov webcite, NCT01174394.

【 授权许可】

   
2014 Man et al.; licensee BioMed Central Ltd.

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