A pilot controlled trial of a combination of dense cranial electroacupuncture stimulation and body acupuncture for post-stroke depression

BMC Complementary and Alternative Medicine

Research Article

Vivian T Wong¹  Eric Ziea¹  Kei-Pui Leung²  Kevin W Y Tsang²  Roger M K Ng³  Mandy P M Fung⁴  Hobby Cheung⁴  Xiao-Chun Yu⁵  Leonard S W Li⁶  Kwok-Pui Leung⁶  Ben H B Hung⁷  Sui-Cheung Man⁷  Zhang-Jin Zhang⁷ 

[1] Chinese Medicine Department, Hospital Authority, Hong Kong, China;Department of Medicine and Rehabilitation, Tung Wah Eastern Hospital, Hong Kong, China;Department of Psychiatry, Kowloon Hospital, Hong Kong, China;Department of Rehabilitation, Kowloon Hospital, Hong Kong, China;Institute of Acupuncture, China Academy of Chinese Medical Sciences, 100700, Dongchen District, Beijing, China;Rehabilitation Unit, Tung Wah Hospital, Hong Kong, China;The School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China;

关键词: Acupuncture;    Post-stroke depression;    Rehabilitation;    Dense cranial electroacupuncture stimulation;    DCEAS;    Clinical trial;   

DOI  :  10.1186/1472-6882-14-255

 received in 2014-01-10, accepted in 2014-07-14,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundOur previous studies have demonstrated the treatment benefits of dense cranial electroacupuncture stimulation (DCEAS), a novel brain stimulation therapy in patients with major depression, postpartum depression and obsessive-compulsive disorder. The purpose of the present study was to further evaluate the effectiveness of DCEAS combined with body acupuncture and selective serotonin reuptake inhibitors (SSRIs) in patients with post-stroke depression (PSD).MethodsIn a single-blind, randomized controlled trial, 43 patients with PSD were randomly assigned to 12 sessions of DCEAS plus SSRI plus body electroacupuncture (n = 23), or sham (non-invasive cranial electroacupuncture, n-CEA) plus SSRI plus body electroacupuncture (n = 20) for 3 sessions per week over 4 weeks. Treatment outcomes were measured using the 17-item Hamilton Depression Rating Scale (HAMD-17), the Clinical Global Impression - Severity scale (CGI-S) and Barthel Index (BI), a measure used to evaluate movement ability associated with daily self-caring activity.ResultsDCEAS produced a significantly greater reduction of both HAMD-17 and CGI-S as early as week 1 and CGI-S at endpoint compared to n-CEA, but subjects of n-CEA group exhibited a significantly greater improvement on BI at week 4 than DCEAS. Incidence of adverse events was not different in the two groups.ConclusionsThese results indicate that DCEAS could be effective in reducing stroke patients’ depressive symptoms. Superficial electrical stimulation in n-CEA group may be beneficial in improving movement disability of stroke patients. A combination of DCEAS and body acupuncture can be considered a treatment option for neuropsychiatric sequelae of stroke.Trial registrationhttp://www.clinicaltrials.gov, NCT01174394.

【 授权许可】

Unknown   
© Man et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.