Potentiometric determination of moxifloxacin in some pharmaceutical formulation using PVC membrane sensors

Chemistry Central Journal

Mohammed M Hefnawy¹  Atef M Homoda²  Mohammed A Abounassif¹  Amer M Alanazi¹  Abdulrahaman Al-Majed¹  Gamal A Mostafa¹ 

[1] Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

[2] Micro-analytical Lab, National Research Center, Dokki, Cairo, Egypt

关键词: Potentiometry;    PVC;    Phosphotungstic acid;    Phosphomolybdic acid;    Sodium tetraphenyl borate;    Moxifloxacin HCl;   

Others  :  1082191
DOI  :  10.1186/s13065-014-0059-y

 received in 2014-05-05, accepted in 2014-09-03,  发布年份 2014

【 摘 要 】

Background

The construction and electrochemical response characteristics of Poly (vinyl chloride) membrane sensors for moxifloxacin HCl (MOX) are described. The sensing membranes incorporate ion association complexes of moxifloxacin cation and sodium tetraphenyl borate (NaTPB) (sensor 1), phosphomolybdic acid (PMA) (sensor 2) or phosphotungstic acid (PTA) (sensor 3) as electroactive materials.

Results

The sensors display a fast, stable and near-Nernstian response over a relative wide moxifloxacin concentration range (1 × 10⁻² - 4.0 × 10⁻⁶, 1 × 10⁻² - 5.0 × 10⁻⁶, 1 × 10⁻² - 5.0 × 10⁻⁶ M), with detection limits of 3 × 10⁻⁶, 4 × 10⁻⁶ and 4.0 × 10⁻⁶ M for sensor 1, 2 and 3, respectively over a pH range of 6.0 - 9.0. The sensors show good discrimination of moxifloxacin from several inorganic and organic compounds. The direct determination of 400 μg/ml of moxifloxacin show an average recovery of 98.5, 99.1 and 98.6% and a mean relative standard deviation of 1.8, 1.6 and 1.8% for sensors 1, 2 and 3 respectively.

Conclusions

The proposed sensors have been applied for direct determination of moxifloxacin in some pharmaceutical preparations. The results obtained by determination of moxifloxacin in tablets using the proposed sensors are comparable favorably with those obtained using the US Pharmacopeia method. The sensors have been used as indicator electrodes for potentiometric titration of moxifloxacin.

【 授权许可】

   
2014 Hefnawy et al.; licensee Chemistry Central Ltd.

【 图 表 】

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