Emergence of Escherichia coli producing OXA-48 β-lactamase in the community in Switzerland

Antimicrobial Resistance and Infection Control

Katrin Zurfluh¹  Magdalena T Nüesch-Inderbinen¹  Laurent Poirel²  Patrice Nordmann²  Herbert Hächler¹  Roger Stephan¹ 

[1] Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Winterthurerstrasse 272, Zurich, 8057, Switzerland

[2] Medical and Molecular Microbiology Unit “Emerging Antibiotic Resistance”, Dept of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland

关键词: OXA-48;    Dissemination;    Enterobacteriaceae;    Community;    Carbapenemase;   

Others  :  1147442
DOI  :  10.1186/s13756-015-0051-x

 received in 2015-01-21, accepted in 2015-03-16,  发布年份 2015

【 摘 要 】

Background

The emergence and worldwide spread of carbapenemase-producing Enterobacteriaceae is of great concern to public health services. The aim of this study was to investigate the occurrence of carbapenemase-producing Enterobacteriaceae in the community in Switzerland.

Findings

One thousand and eighty-six stool samples of healthy humans (staff members of a food-processing company which were screened for the occurrence of salmonellae) were collected in September 2014. After an initial enrichment-step, carbapenemase-producing Enterobacteriaceae were isolated from the carbapenem-containing selective medium SUPERCARBA II. Grown colonies from 11 samples were screened by PCR for the presence of bla_KPC, bla_NDM, bla_OXA-48 and bla_VIM. A single OXA-48-producing Escherichia coli was detected. Phylogenetic grouping and multi-locus sequence typing (MLST) revealed that this strain belonged to D:ST38, a type which had been previously reported in the UK, France, Lebanon and Egypt.

Conclusions

The results of this study show that OXA-48-producing Enterobacteriaceae have started to spread into the community in Switzerland, and a continuous monitoring is necessary to better understand their dissemination in the human population as well as in animals and the environment.

【 授权许可】

   
2015 Zurfluh et al.; licensee BioMed Central.

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