Introduction: Effective educational tools and implementation strategies are important for the dissemination of guideline. We developed the interactive computer-based education program of asthma guideline named as Virtual Learning Center for Asthma Management and evaluated its usefulness in terms of the improvement of awareness and satisfaction. Methods: 170 physicians were enrolled from six tertiary hospitals. They utilized the interactive education program for 2 weeks for the learning of asthma management guideline. We compared awareness of asthma guideline before and after utilization of the program and investigated the user satisfaction with questionnaire survey. Results: Mean age of study subjects was 28.2±3.10 and 78(49.4%) of subjects were male. The total score of awareness of asthma guideline was significantly improved from 80.3±6.39 to 85.1±6.90 (p<0.001). All categories of awareness including knowledge, attitude and practice were improved significantly after learning with the program (p<0.001). Satisfactions of users were high in the aspects of usefulness, convenience, interest, improvement of understanding of guideline and elevation of confidence. The most useful section of the program was virtual cyber management of asthma patients.Conclusion: Interactive education program is a useful and effective tool for dissemination of asthma guideline.